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Identifying a combined biomarker for bisphosphonate-related osteonecrosis of the jaw

Authors
 Ki-Yeol Kim  ;  Xianglan Zhang  ;  In-Ho Cha 
Citation
 Clinical Implant Dentistry and Related Research, Vol.20(2) : 191-198, 2018 
Journal Title
 Clinical Implant Dentistry and Related Research 
ISSN
 1523-0899 
Issue Date
2018
Keywords
bisphosphonate-related osteonecrosis of the jaw ; combined biomarker ; gene expression
Abstract
BACKGROUND: For this study, the aim was to identify combined biomarkers associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Microarray data for GSE7116 were downloaded from the Gene Expression Omnibus database, which contains 26 samples, including without ONJ, and 5 healthy volunteers. The combined biomarkers were identified using principal component analysis, and the pathway enrichment analyses were performed using the DAVID online tool. RESULTS: Two hundred differently expressed genes between groups were detected according to the significances. From functional annotation, Y-box binding protein 1 and heterogeneous nuclear ribonucleoprotein C were found to be included in the most significant 10 pathways. Ten combined gene sets were identified that were effective in classifying multiple myeloma (MM) with ONJ and MM without ONJ. CONCLUSION: Identifying combined gene expression profiles is expected to contribute to more personalized management of BRONJ and to improve existing therapies, and it will be helpful in finding new therapies by identifying more predictive biomarkers.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/cid.12569
DOI
10.1111/cid.12569
Appears in Collections:
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Zhang, Xiang Lan(장향란)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162211
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