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High serum adiponectin is associated with anemia development in chronic kidney disease: The results from the KNOW-CKD study

Authors
 Hyoungnae Kim  ;  Hae-Ryong Yun  ;  Seohyun Park  ;  Jong Hyun Jhee  ;  Jung Tak Park  ;  Tae-Hyun Yoo  ;  Kyu-Beck Lee  ;  Yeong-Hoon Kim  ;  Su-Ah Sung  ;  Joongyub Lee  ;  Shin-Wook Kang  ;  Kyu Hun Choi  ;  Curie Ahn  ;  Seung Hyeok Han 
Citation
 Cytokine, Vol.103 : 43109, 2018 
Journal Title
 Cytokine 
ISSN
 1043-4666 
Issue Date
2018
Keywords
Adiponectin ; Anemia ; Chronic kidney disease
Abstract
BACKGROUND: Adiponectin is an adipokine secreted by adipocytes. A low adiponectin level is a significant risk factor of diabetes mellitus and cardiovascular disease. Recent studies have shown that adiponectin is negatively associated with hematopoiesis and predicts the development of anemia in the general population. In chronic kidney disease (CKD) patients, circulating adiponectin level is paradoxically elevated and the role of adiponectin is complex. Therefore, we evaluated the relationship between adiponectin and anemia in these patients. METHODS: This prospective longitudinal study included 2113 patients from the KNOW-CKD study (KoreaN cohort study for Outcome in patients With CKD), after excluding 125 without data on adiponectin levels. Hemoglobin levels were measured yearly during a mean follow-up period of 23.7months. Anemia was defined as hemoglobin levels of <13.0 and 12.0g/dL for men and women, respectively. RESULTS: Mean patient age was 53.6+/-12.2years, and 1289 (61%) were men. The mean estimated glomerular filtration rate (eGFR) was 50.4+/-30.2mLmin(-1)1.73m(-2). Serum adiponectin level was inversely associated with body mass index, eGFR, log-transformed C-reactive protein, and positively with Charlson comorbidity index, urine protein to creatinine ratio, and high density lipoprotein cholesterol. In addition, serum adiponectin level was also negatively correlated with hemoglobin level and reticulocyte production index in both men and women. In multivariable linear regression analysis after adjustment of multiple confounders, adiponectin was negatively associated with hemoglobin (men, beta=-0.219, P<.001; women, beta=-0.09, P=.025). Among 1227 patients without anemia at baseline, 307 newly developed anemia during the follow-up period. In multivariable Cox regression analysis after adjustment of confounders, high adiponectin level was significantly associated with an increased risk of incident anemia (per 1microg/mL increase, hazard ratio, 1.02; 95% confidence interval 1.01-1.04; P=.001). CONCLUSIONS: A high serum adiponectin level is independently associated with a low hemoglobin level and predicts the development of anemia in patients with CKD. These findings reveal the potential role of adiponectin in CKD-related anemia.
Full Text
https://www.sciencedirect.com/science/article/pii/S1043466617303897
DOI
10.1016/j.cyto.2017.12.018
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강신욱(Kang, Shin Wook) ORCID logo https://orcid.org/0000-0002-5677-4756
박서현(Park, Seo Hyun)
박정탁(Park, Jung Tak) ORCID logo https://orcid.org/0000-0002-2325-8982
유태현(Yoo, Tae Hyun) ORCID logo https://orcid.org/0000-0002-9183-4507
윤해룡(Yun, Hae Ryong) ORCID logo https://orcid.org/0000-0002-7038-0251
지종현(Jhee, Jong Hyun)
최규헌(Choi, Kyu Hun)
한승혁(Han, Seung Hyeok) ORCID logo https://orcid.org/0000-0001-7923-5635
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162160
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