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Comparison of CPI and GAP models in patients with idiopathic pulmonary fibrosis: a nationwide cohort study

Authors
 Sang Hoon Lee  ;  Jong Sun Park  ;  Song Yee Kim  ;  Dong Soon Kim  ;  Young Whan Kim  ;  Man Pyo Chung  ;  Soo Taek Uh  ;  Choon Sik Park  ;  Sung Woo Park  ;  Sung Hwan Jeong  ;  Yong Bum Park  ;  Hong Lyeol Lee  ;  Jong Wook Shin  ;  Eun Joo Lee  ;  Jin Hwa Lee  ;  Yangin Jegal  ;  Hyun Kyung Lee  ;  Yong Hyun Kim  ;  Jin Woo Song  ;  Moo Suk Park 
Citation
 Scientific Reports, Vol.8(1) : 4784, 2018 
Journal Title
 Scientific Reports 
Issue Date
2018
Abstract
The clinical course of idiopathic pulmonary fibrosis (IPF) is difficult to predict, partly owing to its heterogeneity. Composite physiologic index (CPI) and gender-age-physiology (GAP) models are easy-to-use predictors of IPF progression. This study aimed to compare the predictive values of these two models. From 2003 to 2007, the Korean Interstitial Lung Disease (ILD) Study Group surveyed ILD patients using the 2002 ATS/ERS criteria. A total of 832 patients with IPF were enrolled in this study. CPI was calculated as follows: 91.0 - (0.65 x %DLCO) - [0.53 x %FVC + [0.34 x %FEV1. GAP stage was calculated based on gender (0-1 points), age (0-2 points), and two physiologic lung function parameters (0-5 points). The two models had similar significant predictive values for patients with IPF (p < 0.001). The area under the curve (AUC) was higher for CPI than GAP for prediction of 1-, 2-, and 3-year mortality in this study. The AUC was higher for surgically diagnosed IPF patients than for clinically diagnosed patients. However, neither CPI nor GAP yielded good predictions of outcomes; the AUC was approximately 0.61~0.65. Although both CPI and GAP stage are significantly useful predictors for IPF, they have limited capability to accurately predict outcomes.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162147
Files in This Item:
T201800969.pdf Download
DOI
10.1038/s41598-018-23073-3
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김송이(Kim, Song Yee) ORCID logo https://orcid.org/0000-0001-8627-486X
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
이상훈(Lee, Sang Hoon) ORCID logo https://orcid.org/0000-0002-7706-5318
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