Cited 20 times in
Macrophage polarization and acceleration of atherosclerotic plaques in a swine model
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2018-08-28T16:57:55Z | - |
dc.date.available | 2018-08-28T16:57:55Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162117 | - |
dc.description.abstract | AIMS: Atherosclerosis is a well-known cause of cardiovascular disease and is associated with a variety of inflammatory reactions. However, an adequate large-animal model of advanced plaques to investigate the pathophysiology of atherosclerosis is lacking. Therefore, we developed and assessed a swine model of advanced atherosclerotic plaques with macrophage polarization. METHODS: Mini-pigs were fed a 2% high-cholesterol diet for 7 weeks followed by withdrawal periods of 4 weeks. Endothelial denudation was performed using a balloon catheter on 32 coronary and femoral arteries of 8 mini-pigs. Inflammatory proteins (high-mobility group box 1 [HMGB1] or tumor necrosis factor alpha (TNF-alpha) were injected via a micro-infusion catheter into the vessel wall. All lesions were assessed with angiography and optical coherence tomography and all tissues were harvested for histological evaluation. RESULTS: Intima/plaque area was significantly higher in the HMGB1- and TNF-alpha-injected groups compared to the saline-injected group (p = 0.002). CD68 antibody detection and polarization of M1 macrophages significantly increased in the inflammatory protein-injected groups (p<0.001). In addition, advanced atherosclerotic plaques were observed more in the inflammatory protein-injected groups compared with the control upon histologic evaluation. CONCLUSION: Direct injection of inflammatory proteins was associated with acceleration of atherosclerotic plaque formation with M1 macrophage polarization. Therefore, direct delivery of inflammatory proteins may induce a pro-inflammatory response, providing a possible strategy for development of an advanced atherosclerotic large-animal model in a relatively short time period. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Atherosclerosis/*metabolism/pathology | - |
dc.subject.MESH | Animal Disease Models | - |
dc.subject.MESH | HMGB1 Protein/*metabolism | - |
dc.subject.MESH | Macrophages/*metabolism/pathology | - |
dc.subject.MESH | Atherosclerotic/*metabolism/pathology Plaque | - |
dc.subject.MESH | Swine | - |
dc.subject.MESH | Miniature Swine | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/*metabolism | - |
dc.subject.MESH | Tunica Intima/*metabolism/pathology | - |
dc.title | Macrophage polarization and acceleration of atherosclerotic plaques in a swine model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Seul-Gee Lee | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Sung-Kyung Bong | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Seil Park | - |
dc.contributor.googleauthor | Sehoon Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | 10.1371/journal.pone.0193005 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02395 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 29561847 | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Oh, Jae Won | - |
dc.contributor.alternativeName | Lee, Snag Hak | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Oh, Jae Won | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e0193005 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.13(3) : e0193005, 2018 | - |
dc.identifier.rimsid | 59706 | - |
dc.type.rims | ART | - |
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