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Metabolic characteristics of solid pseudopapillary neoplasms of the pancreas: their relationships with high intensity (18)F-FDG PET images

 Minhee Park  ;  Ho Kyoung Hwang  ;  Mijin Yun  ;  Woo Jung Lee  ;  Hoguen Kim  ;  Chang Moo Kang 
 Oncotarget, Vol.9(15) : 12009-12019, 2018 
Journal Title
Issue Date
18F-FDG-PET ; metabolism ; metabolomics ; pancreatectomy ; solid pseudopapillary neoplasm
Objective: We aimed to investigate the metabolic characteristics of Solid pseudopapillary neoplasms (SPNs) in relation signal intensities on (18)F-FDG PET scans. Summary Background Data: SPNs of the pancreas commonly show high uptake of 18F-FDG. However, the metabolic characteristics underlying the high (18)F-FDG uptake in SPNs are not well characterized. Materials and Methods: mRNA expressions for glucose metabolism were analyzed in five SPNs, five pancreatic ductal adenocarcinomas (PCAs), and paired normal pancreatic tissues. Among the proteins involved in glucose metabolism, the expressions of five proteins (GLUT1, HK1, PFKM, ENO2, and PKM2) were evaluated in 36 SPNs by immunohistochemistry. Clinical patterns of SPN on PET scans were classified according to the proportion of (18)F-FDG uptake within the whole tumor volume (hot: >/= 70%, mixed: 30 </= < 70, and defective: < 30%). PET-based parameters, including maximum standardized uptake value (SUVmax) and metabolic tumor volume (TMV2.5), were evaluated. Results: Hot (n = 19), mixed (n = 5), and defective (n = 12) (18)F-FDG uptake patterns were noted in the 36 patients. Radiologic tumor size and SUVmax differed significantly according to these patterns (ANOVA, p < 0.05). GLUT1, HK1, PFKM, ENO2, and PKM2 were highly expressed in SPNs at both the mRNA and protein levels. Defective type SPNs showed lower expression of HK1 (p = 0.014), PKM2 (p = 0.028), and Ki-67 (p = 0.070) with frequent intra-tumoral necrosis (p = 0.007). High Ki-67 expression (>/= 3%) was associated with high SUVmax in pancreatic SPNs (p = 0.002). Conclusions: SPN cells harbor an active molecular capacity for increased glucose metabolism. Especially, defective type SPNs were associated with low metabolic activity and related to low Ki-67 index.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
강창무(Kang, Chang Moo) ORCID logo https://orcid.org/0000-0002-5382-4658
김호근(Kim, Ho Keun)
박민희(Park, Min Hee)
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이우정(Lee, Woo Jung) ORCID logo https://orcid.org/0000-0001-9273-261X
황호경(Hwang, Ho Kyoung) ORCID logo https://orcid.org/0000-0003-4064-7776
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