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Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis

Authors
 Jun Li  ;  Younghee Kwon  ;  Kyung Soo Chung  ;  Chang Su Lim  ;  Dayoung Lee  ;  Yongkang Yue  ;  Jisoo Yoon  ;  Gyoungmi Kim  ;  Sang-Jip Nam  ;  Youn Wook Chung  ;  Hwan Myung Kim  ;  Caixia Yin  ;  Ji-Hwan Ryu  ;  Juyoung Yoon 
Citation
 THERANOSTICS, Vol.8(5) : 1411-1420, 2018 
Journal Title
 THERANOSTICS 
Issue Date
2018
Keywords
GSH ; Sepsis ; cell imaging ; diagnosis ; fluorescence probe
Abstract
Rationale: Among the biothiols-related diseases, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and can result in severe oxidative stress and damage to multiple organs. In this study, we aimed to develop a fluorescence chemosensor that can both detect GSH and further predict sepsis. Methods: In this study, two new naphthalene dialdehyde compounds containing different functional groups were synthesized, and the sensing abilities of these compounds towards biothiols and its applications for prediction of sepsis were investigated. Results: Our study revealed that the newly developed probe 6-methoxynaphthalene-2, 3-dicarbaldehyde (MNDA) has two-photon is capable of detecting GSH in live cells with two-photon microscopy (TPM) under the excitation at a wavelength of 900 nm. Furthermore, two GSH detection probes naphthalene-2,3-dicarboxaldehyde (NDA) and 6-fluoronaphthalene-2,3-dicarbaldehyde (FNDA) not only can detect GSH in living cells, but also showed clinical significance for the diagnosis and prediction of mortality in patients with sepsis. Conclusions: These results open up a promising direction for further medical diagnostic techniques.
Files in This Item:
T201800576.pdf Download
DOI
10.7150/thno.22252
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Ji Hwan(유지환)
Jung, Kyung Soo(정경수) ORCID logo https://orcid.org/0000-0003-1604-8730
Chung, Youn Wook(정연욱) ORCID logo https://orcid.org/0000-0002-4382-1410
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162075
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