0 113

Cited 15 times in

Head to head comparison of [(18)F] AV-1451 and [(18)F] THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia

Authors
 Young Kyoung Jang  ;  Chul Hyoung Lyoo  ;  Seongbeom Park  ;  Seung Jun Oh  ;  Hanna Cho  ;  Minyoung Oh  ;  Young Hoon Ryu  ;  Jae Yong Choi  ;  Gil D Rabinovici  ;  Hee Jin Kim  ;  Seung Hwan Moon  ;  Hyemin Jang  ;  Jin San Lee  ;  William J Jagust  ;  Duk L Na  ;  Jae Seung Kim  ;  Sang Won Seo 
Citation
 European Journal of Nuclear Medicine and Molecular Imaging, Vol.45(3) : 432-442, 2018 
Journal Title
 European Journal of Nuclear Medicine and Molecular Imaging 
ISSN
 1619-7070 
Issue Date
2018
Keywords
Alzheimer's disease ; Av-1451 ; Frontotemporal dementia ; THK5351 ; Tau
Abstract
PURPOSE: Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer's disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [(18)F] AV-1451 and [(18)F] THK5351 have been developed to detect tau deposition in vivo. In the present study, we performed a head to head comparison of these two tracers in Alzheimer's disease and frontotemporal dementia cases and aimed to investigate which tracers are better suited to image tau in these disorders. METHODS: A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We recruited eight participants (two Alzheimer's disease, four frontotemporal dementia and two normal controls) who underwent magnetic resonance image, amyloid positron emission tomography with [(18)F]-Florbetaben and tau positron emission tomography with both THK5351 and AV-1451. To measure regional AV1451 and THK5351 uptakes, we used the standardized uptake value ratios by dividing mean activity in target volume of interest by mean activity in the cerebellar hemispheric gray matter. RESULTS: Although THK5351 and AV-1451 uptakes were highly correlated, cortical uptake of AV-1451 was more striking in Alzheimer's disease, while cortical uptake of THK5351 was more prominent in frontotemporal dementia. THK5351 showed higher off-target binding than AV-1451 in the white matter, midbrain, thalamus, and basal ganglia. CONCLUSIONS: AV-1451 is more sensitive and specific to Alzheimer's disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.
Full Text
https://link.springer.com/article/10.1007%2Fs00259-017-3876-0
DOI
10.1007/s00259-017-3876-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162047
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse