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Role of Radiation Therapy in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Guidelines from the International Lymphoma Radiation Oncology Group

Authors
 Andrea K Ng  ;  Joachim Yahalom  ;  Jayant S Goda  ;  Louis S Constine  ;  Chelsea C Pinnix  ;  Chris R Kelsey  ;  Bradford Hoppe  ;  Masahiko Oguchi  ;  Chang-Ok Suh  ;  Andrew Wirth  ;  Shunan Qi  ;  Andrew Davies  ;  Craig H Moskowitz  ;  Siddhartha Laskar  ;  Yexiong Li  ;  Peter M Mauch  ;  Lena Specht  ;  Timothy Illidge 
Citation
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.100(3) : 652-669, 2018 
Journal Title
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 
ISSN
 0360-3016 
Issue Date
2018
Abstract
Approximately 30% to 40% of patients with diffuse large B-cell lymphoma (DLBCL) will have either primary refractory disease or relapse after chemotherapy. In transplant-eligible patients, those with disease sensitive to salvage chemotherapy will significantly benefit from high-dose therapy with autologous stem cell transplantation. The rationale for considering radiation therapy (RT) for selected patients with relapsed/refractory DLBCL as a part of the salvage program is based on data regarding the patterns of relapse and retrospective series showing improved local control and clinical outcomes for patients who received peritransplant RT. In transplant-ineligible patients, RT can provide effective palliation and, in selected cases, be administered with curative intent if the relapsed/refractory disease is localized. We have reviewed the indications for RT in the setting of relapsed/refractory DLBCL and provided recommendations regarding the optimal timing of RT, dose fractionation scheme, and treatment volume in the context of specific case scenarios.
Full Text
https://www.sciencedirect.com/science/article/pii/S0360301617341871
DOI
10.1016/j.ijrobp.2017.12.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Suh, Chang Ok(서창옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162020
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