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Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: A prospective, placebo-controlled, multicenter study

 Hyun-Jin Lee  ;  Min-Beom Kim  ;  Shin-Young Yoo  ;  Shi Nae Park  ;  Eui-Cheol Nam  ;  In Seok Moon  ;  Ho-Ki Lee 
 LARYNGOSCOPE, Vol.128(1) : 184-188, 2018 
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Issue Date
Adolescent ; Adult ; Aged ; Dexamethasone/*administration & dosage ; Disability Evaluation ; Double-Blind Method ; Female ; Glucocorticoids/*administration & dosage ; Humans ; Intratympanic Injection ; Male ; Middle Aged ; Prospective Studies ; Republic of Korea ; Tinnitus/*drug therapy ; Treatment Outcome
Intratympanic dexamethasone injection ; tinnitus
OBJECTIVE: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. STUDY DESIGN: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. METHODS: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization. Intratympanic injections were administered four times over 2 weeks. At 4 weeks after initial injection, we analyzed the improvement rates of tinnitus using the tinnitus handicap Inventory (THI) and visual analogue scale (VAS) for loudness, awareness, and annoyance. We defined improvement as the reduction of more than 7 points or of more than 20% in the final THI score compared to the initial THI score. RESULTS: The initial mean hearing thresholds and VAS and THI scores of the two groups did not differ significantly. At 4 weeks after initial injection, the mean VAS and THI scores of both groups had significantly reduced. However, the improvement rate did not differ significantly between the groups (ITDI, 51.9%; ITNI, 59.3%). CONCLUSION: The results indicate that ITDI might not be more effective than ITNI for the treatment of acute unilateral tinnitus. Therefore, ITDI should not be considered as the main treatment for patients presenting with acute tinnitus as the primary symptom. LEVEL OF EVIDENCE: 1b. Laryngoscope, 128:184-188, 2018.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Moon, In Seok(문인석) ORCID logo https://orcid.org/0000-0002-3951-5074
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