Cited 0 times in
Immunohistochemical Analysis on Cortex-to-Cortex Healing After Mandibular Vertical Ramus Osteotomy: A Preliminary Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박형식 | - |
dc.contributor.author | 정영수 | - |
dc.contributor.author | 정한성 | - |
dc.contributor.author | 정휘동 | - |
dc.date.accessioned | 2018-08-28T16:50:02Z | - |
dc.date.available | 2018-08-28T16:50:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0278-2391 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161986 | - |
dc.description.abstract | PURPOSE: The present study analyzed the expression of specific cytokines in the transforming growth factor (TGF)-beta superfamily postoperatively after mandibular vertical ramus osteotomy (VRO). MATERIALS AND METHODS: Four beagle dogs were enrolled and euthanized at 1, 2, 4, and 8 weeks postoperatively for immunohistochemical analysis using 6 specific antibodies (bone morphogenetic protein [BMP]-2/4, BMP-7, TGF-beta2, TGF-beta3, matrix metalloproteinase-3, and vascular endothelial growth factor [VEGF]). The results from the surgical site and control (adjacent area) were compared. RESULTS: Generalized upregulation of BMP-2/4 was observed in all healing periods, and the strongest expression of BMP-7 was observed at 1 week postoperatively. The strongest expression of TGF-beta2 was observed at 8 weeks with increasing pattern. The strong expression of TGF-beta3 was observed at 1 and 4 weeks, with the strongest expression of VEGF at 1 week, with a decreasing pattern. No notable uptake was detected with the 6 specific antibodies in the adjacent bone (control). CONCLUSIONS: The absence of internal fixation after VRO led to dynamic healing with a specific expression pattern of BMP-7 and TGF-beta2. The anatomic factors, including sufficient preexisting vascularity, led to the earlier expression pattern of VEGF. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | W.B. Saunders Co. | - |
dc.relation.isPartOf | JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Immunohistochemical Analysis on Cortex-to-Cortex Healing After Mandibular Vertical Ramus Osteotomy: A Preliminary Study | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral and Maxillofacial Surgery | - |
dc.contributor.googleauthor | Hwi-Dong Jung | - |
dc.contributor.googleauthor | Sang Yoon Kim | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.contributor.googleauthor | Hyung-Sik Park | - |
dc.contributor.googleauthor | Young-Soo Jung | - |
dc.identifier.doi | 10.1016/j.joms.2017.10.004 | - |
dc.contributor.localId | A01755 | - |
dc.contributor.localId | A03655 | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A03792 | - |
dc.relation.journalcode | J01659 | - |
dc.identifier.eissn | 1531-5053 | - |
dc.identifier.pmid | 29112826 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0278239117312727 | - |
dc.contributor.alternativeName | Park, Hyung Sik | - |
dc.contributor.alternativeName | Jung, Young Soo | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.alternativeName | Jung, Hwi Dong | - |
dc.contributor.affiliatedAuthor | Park, Hyung Sik | - |
dc.contributor.affiliatedAuthor | Jung, Young Soo | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Jung, Hwi Dong | - |
dc.citation.volume | 76 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 437.e1 | - |
dc.citation.endPage | 437.e8 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.76(2) : 437.e1-437.e8, 2018 | - |
dc.identifier.rimsid | 59577 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.