Cited 1 times in
Infarct Core Expansion on Computed Tomography before and after Intravenous Thrombolysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영대 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 송동범 | - |
dc.contributor.author | 유준상 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2018-08-28T16:48:34Z | - |
dc.date.available | 2018-08-28T16:48:34Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161961 | - |
dc.description.abstract | PURPOSE: Infarct core can expand rapidly in acute stroke patients receiving intravenous tissue plasminogen activator (IV t-PA). We investigated changes in the extent of infarct core during IV t-PA treatment, and explored the associative factors of this infarct core expansion in patients with proximal artery occlusion. MATERIALS AND METHODS: We included patients who were considered for sequential intra-arterial therapy (IAT) due to occlusion of intracranial proximal artery after IV t-PA. Patients who had a baseline Alberta Stroke Program Early Computed Tomography (CT) Score (ASPECTS) >/=6 and who underwent two consecutive CT scans before and shortly after IV t-PA infusion were enrolled. Patients were classified into no, moderate, and marked expansion groups based on decreases in ASPECTS (0-1, 2-3, and >/=4, respectively) on follow-up CT. Collateral status was graded using CT angiography. RESULTS: Of the 104 patients, 16 (15.4%) patients showed moderate and 13 (12.5%) patients showed marked infarct core expansion on follow-up CT scans obtained at 71.1+/-19.1 min after baseline CT scan. Sixteen (15.4%) patients had an ASPECTS value <6 on the follow-up CT. None of the patients with marked expansion were independent at 3 months. Univariate analysis and ordinal logistic regression analysis demonstrated that the infarct core expansion was significantly associated with collateral status (p<0.001). CONCLUSION: Among patients who were considered for IAT after IV t-PA treatment, one out of every seven patients exhibited marked expansion of infarct core on follow-up CT before IAT. These patients tend to have poor collaterals and poor outcomes despite rescue IAT. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Intravenous Administration | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Brain Infarction/*diagnostic imaging/*therapy | - |
dc.subject.MESH | Computed Tomography Angiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrinolytic Agents/therapeutic use | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | *Thrombolytic Therapy | - |
dc.subject.MESH | X-Ray Computed/*methods Tomography | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Infarct Core Expansion on Computed Tomography before and after Intravenous Thrombolysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Dongbeom Song | - |
dc.contributor.googleauthor | Joonsang Yoo | - |
dc.contributor.googleauthor | Jang Hyun Baek | - |
dc.contributor.googleauthor | Jinkwon Kim | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Young Dae Kim | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.identifier.doi | 10.3349/ymj.2018.59.2.310 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A02017 | - |
dc.contributor.localId | A02513 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 29436201 | - |
dc.subject.keyword | Acute stroke therapy | - |
dc.subject.keyword | CT scan | - |
dc.subject.keyword | collateral circulation | - |
dc.subject.keyword | ischemic stroke | - |
dc.subject.keyword | tissue plasminogen activator | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.alternativeName | Song, Dong Beom | - |
dc.contributor.alternativeName | Yoo, Joon Sang | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Song, Dong Beom | - |
dc.contributor.affiliatedAuthor | Yoo, Joon Sang | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.citation.volume | 59 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 310 | - |
dc.citation.endPage | 316 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.59(2) : 310-316, 2018 | - |
dc.identifier.rimsid | 59552 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.