0 83

Cited 2 times in

Exogenous ROS-induced cell sheet transfer based on hematoporphyrin-polyketone film via a one-step process

DC FieldValueLanguage
dc.contributor.author권병주-
dc.contributor.author박종철-
dc.contributor.author이미희-
dc.contributor.author구민아-
dc.contributor.author선경미-
dc.date.accessioned2018-08-28T16:47:02Z-
dc.date.available2018-08-28T16:47:02Z-
dc.date.issued2018-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161931-
dc.description.abstractTo date, most of invasive cell sheet harvesting methods have used culture surface property variations, such as wettability, pH, electricity, and magnetism, to induce cell detachment. These methods that rely on surface property changes are effective when cell detachment prior to application is necessary, but of limited use when used for cell sheet transfer to target regions. The study reports a new reactive oxygen species (ROS)-induced strategy based on hematoporphyrin-incorporated polyketone film (Hp-PK film) to transfer cell sheets directly to target areas without an intermediate harvesting process. After green LED (510nm) irradiation, production of exogenous ROS from the Hp-PK films induces cell sheet detachment and transfer. The study suggests that ROS-induced cell detachment property of the Hp-PK film is closely related to conformational changes of extracellular matrix (ECM) proteins. Also, this strategy with the Hp-PK film can be applied by regulating production rate of exogenous ROS in various types of cells, including fibroblasts, mesenchymal stem cells and keratinocytes. In conclusion, ROS-induced method using the Hp-PK film can be used for one-step cell sheet transplantation and has potential in biomedical applications.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfBiomaterials-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleExogenous ROS-induced cell sheet transfer based on hematoporphyrin-polyketone film via a one-step process-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Medical Engineering-
dc.contributor.googleauthorMin-Ah Koo-
dc.contributor.googleauthorMi Hee Lee-
dc.contributor.googleauthorByeong-Ju Kwon-
dc.contributor.googleauthorGyeung Mi Seon-
dc.contributor.googleauthorMin Sung Kim-
dc.contributor.googleauthorDohyun Kim-
dc.contributor.googleauthorKi Chang Nam-
dc.contributor.googleauthorJong-Chul Park-
dc.identifier.doi10.1016/j.biomaterials.2018.01.030-
dc.contributor.localIdA00218-
dc.contributor.localIdA01662-
dc.contributor.localIdA02777-
dc.relation.journalcodeJ00312-
dc.identifier.eissn1878-5905-
dc.identifier.pmid29421562-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0142961218300449-
dc.subject.keywordCell sheet detachment-
dc.subject.keywordExogenous ROS-
dc.subject.keywordExtracellular matrix-
dc.subject.keywordHp-PK film-
dc.contributor.alternativeNameKwon, Byeong Ju-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameLee, Mi Hee-
dc.contributor.affiliatedAuthorKwon, Byeong Ju-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.contributor.affiliatedAuthorLee, Mi Hee-
dc.citation.volume161-
dc.citation.startPage47-
dc.citation.endPage56-
dc.identifier.bibliographicCitationBiomaterials, Vol.161 : 47-56, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.