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Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (2006-2010): a Retrospective Multicenter Study

 Kyuyol Rhie  ;  Eun Hwa Choi  ;  Eun Young Cho  ;  Jina Lee  ;  Jin Han Kang  ;  Dong Soo Kim  ;  Yae Jean Kim  ;  Youngmin Ahn  ;  Byung Wook Eun  ;  Sung Hee Oh  ;  Sung Ho Cha  ;  Young Jin Hong  ;  Kwang Nam Kim  ;  Nam Hee Kim  ;  Yun Kyung Kim  ;  Jong Hyun Kim  ;  Taekjin Lee  ;  Hwang Min Kim  ;  Kun Song Lee  ;  Chun Soo Kim  ;  Su Eun Park  ;  Young Mi Kim  ;  Chi Eun Oh  ;  Sang Hyuk Ma  ;  Dae Sun Jo  ;  Young Youn Choi  ;  Hoan Jong Lee 
 Journal of Korean Medical Science, Vol.33(6) : e45, 2018 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Bacterial Infections ; Epidemiology ; Escherichia coli ; Staphylococcus aureus ; Streptococcus agalactiae ; Streptococcus pneumoniae
BACKGROUND: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. METHODS: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. RESULTS: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children >/= 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996-2010) in children >/= 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and >/= 3 months of age groups (P < 0.001). CONCLUSION: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
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