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Liquid-Based Cytology of the Cerebrospinal Fluid in a Case of Cryptococcal Meningitis

Authors
 Jiwoon Choi  ;  Se Hoon Kim 
Citation
 Journal of Pathology and Translational Medicine, Vol.52(1) : 61-63, 2018 
Journal Title
 Journal of Pathology and Translational Medicine 
ISSN
 2383-7837 
Issue Date
2018
Keywords
Cerebrospinal fluid ; Cryptococcus neoformans ; Liquid-based cytology
Abstract
Cryptococcus neoformans is the most common microorganism found in cerebrospinal fluid (CSF) cytology and causes life-threatening infections in immunocompromised hosts. Although its cytomorphologic features in conventional smear cytology have been well described, those in liquid-based cytology have rarely been. A 73-year-old woman with diffuse large B-cell lymphoma presented with mental confusion and a spiking fever. To rule out infectious conditions, CSF examination was performed. A cytology slide that was prepared using the ThinPrep method showed numerous spherical yeast-form organisms with diameters of 4-11 mum and thick capsules. Occasional asymmetrical, narrow-based budding but no true hyphae or pseudohyphae were observed. Gomori methenamine silver staining was positive. Cryptococcosis was confirmed in blood and CSF through the cryptococcal antigen test and culture. Liquid-based cytology allows for a clean background and additional slides for ancillary testing, facilitating the detection of microorganisms in CSF specimens, particularly when the number of organisms is small.
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T201800187.pdf Download
DOI
10.4132/jptm.2017.06.13
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김세훈(Kim, Se Hoon) ORCID logo https://orcid.org/0000-0001-7516-7372
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161883
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