85 141

Cited 3 times in

Radiotherapy Versus Cordectomy in the Management of Early Glottic Cancer

 Seung Yeun Chung  ;  Kyung Hwan Kim  ;  Ki Chang Keum  ;  Yoon Woo Koh  ;  Se-Heon Kim  ;  Eun Chang Choi  ;  Chang Geol Lee 
 CANCER RESEARCH AND TREATMENT, Vol.50(1) : 156-163, 2018 
Journal Title
Issue Date
Laryngeal neoplasms ; Local neoplasm recurrence ; Radiotherapy
PURPOSE: The purpose of this study was to compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. MATERIALS AND METHODS: A total of 165 patients who were diagnosedwith T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), disease-free survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated. RESULTS: The median follow-up period was 77.7 months (range, 10.7 to 127.0 months). The 3- and 5-year LC rates were 91.9% and 89.9%, respectively, for the RT group, and 82.8% and 73.2%, respectively, for the cordectomy group (p=0.006). The 3- and 5-year DFS rates were 87.5% and 83.7%, respectively, for the RT group and 79.2% and 68.0%, respectively, for the cordectomy group (p=0.046). No significant differences were identified in the 5-year OS (92.8% vs. 90.6%, p=0.713) or larynx preservation rates (98.2% vs. 97.2%, p=0.831) between groups. The major failure pattern was local failure (n=26), followed by regional (n=3) and distant failure (n=2). Multivariate analysis of LC showed that T2 stage (p=0.012) and receiving cordectomy as initial treatment (p=0.001) were significantly associated with poorer LC. CONCLUSION: RT resulted in higher rates of LC and DFS compared to cordectomy for early glottic cancer. Treatment with radiotherapy is feasible and should be encouraged for both T1 and T2 glottic cancer.
Files in This Item:
T201800154.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kho, Yoon Woo(고윤우)
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Se Heon(김세헌)
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
Chung, Seung Yeun(정승연) ORCID logo https://orcid.org/0000-0002-3877-6950
Choi, Eun Chang(최은창)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.