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Radiotherapy Versus Cordectomy in the Management of Early Glottic Cancer

Authors
 Seung Yeun Chung  ;  Kyung Hwan Kim  ;  Ki Chang Keum  ;  Yoon Woo Koh  ;  Se-Heon Kim  ;  Eun Chang Choi  ;  Chang Geol Lee 
Citation
 Cancer Research and Treatment, Vol.50(1) : 156-163, 2018 
Journal Title
 Cancer Research and Treatment 
ISSN
 1598-2998 
Issue Date
2018
Keywords
Laryngeal neoplasms ; Local neoplasm recurrence ; Radiotherapy
Abstract
PURPOSE: The purpose of this study was to compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. MATERIALS AND METHODS: A total of 165 patients who were diagnosedwith T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), disease-free survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated. RESULTS: The median follow-up period was 77.7 months (range, 10.7 to 127.0 months). The 3- and 5-year LC rates were 91.9% and 89.9%, respectively, for the RT group, and 82.8% and 73.2%, respectively, for the cordectomy group (p=0.006). The 3- and 5-year DFS rates were 87.5% and 83.7%, respectively, for the RT group and 79.2% and 68.0%, respectively, for the cordectomy group (p=0.046). No significant differences were identified in the 5-year OS (92.8% vs. 90.6%, p=0.713) or larynx preservation rates (98.2% vs. 97.2%, p=0.831) between groups. The major failure pattern was local failure (n=26), followed by regional (n=3) and distant failure (n=2). Multivariate analysis of LC showed that T2 stage (p=0.012) and receiving cordectomy as initial treatment (p=0.001) were significantly associated with poorer LC. CONCLUSION: RT resulted in higher rates of LC and DFS compared to cordectomy for early glottic cancer. Treatment with radiotherapy is feasible and should be encouraged for both T1 and T2 glottic cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161864
DOI
10.4143/crt.2016.503
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
Yonsei Authors
고윤우(Kho, Yoon Woo) ; 금기창(Keum, Ki Chang) ; 김세헌(Kim, Se Heon) ; 이창걸(Lee, Chang Geol) ; 최은창(Choi, Eun Chang)
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