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Comparison of Clinical Features and Outcomes in Epithelial Ovarian Cancer according to Tumorigenicity in Patient-Derived Xenograft Models

Authors
 Kyung Jin Eoh  ;  Young Shin Chung  ;  So Hyun Lee  ;  Sun-Ae Park  ;  Hee Jung Kim  ;  Wookyeom Yang  ;  In Ok Lee  ;  Jung-Yun Lee  ;  Hanbyoul Cho  ;  Doo Byung Chay  ;  Sunghoon Kim  ;  Sang Wun Kim  ;  Jae-Hoon Kim  ;  Young Tae Kim  ;  Eun Ji Nam 
Citation
 Cancer Research and Treatment, Vol.50(3) : 956-963, 2018 
Journal Title
 Cancer Research and Treatment 
Issue Date
2018
Keywords
Ovarian neoplasms ; Patient-derived xenograft ; Progression-free survival
Abstract
Purpose: Although the use of xenograft models is increasing, few studies have compared the clinical features or outcomes of epithelial ovarian cancer (EOC) patients according to the tumorigenicity of engrafted specimens. The purpose of this study was to evaluate whether tumorigenicity was associated with the clinical features and outcomes of EOC patients. Materials and Methods: Eighty-eight EOC patients who underwent primary or interval debulking surgery from June 2014 to December 2015 were included. Fresh tumor specimens were implanted subcutaneously on each flank of immunodeficient mice. Patient characteristics, progression-free survival (PFS), and germline mutation spectra were compared according to tumorigenicity. Results: Xenografts were established successfully from 49 of 88 specimens. Tumorigenicity was associated with lymphovascular invasion and there was a propensity to engraft successfully with high-grade tumors. Tumors from patients who underwent non-optimal (residual disease ≥ 1 cm) primary or interval debulking surgery had a significantly greater propensity to achieve tumorigenicity than those who received optimal surgery. In addition, patients whose tumors became engrafted seemed to have a shorter PFS and more frequent germline mutations than patients whose tumors failed to engraft. Tumorigenicity was a significant factor for predicting PFS with advanced International Federation of Gynecology and Obstetrics stage and high-grade cancers. Conclusions: Tumorigenicity in a xenograft model was a strong prognostic factor and was associated with more aggressive tumors in EOC patients. Xenograft models can be useful as a preclinical tool to predict prognosis and could be applied to further pharmacologic and genomic studies on personalized treatments.
Files in This Item:
T201802167.pdf Download
DOI
10.4143/crt.2017.181
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
Yonsei Authors
김상운(Kim, Sang Wun) ORCID logo https://orcid.org/0000-0002-8342-8701
김성훈(Kim, Sung Hoon) ORCID logo https://orcid.org/0000-0002-1645-7473
김영태(Kim, Young Tae) ORCID logo https://orcid.org/0000-0002-7347-1052
김재훈(Kim, Jae Hoon) ORCID logo https://orcid.org/0000-0001-6599-7065
남은지(Nam, Eun Ji)
어경진(Eoh, Kyung Jin) ORCID logo https://orcid.org/0000-0002-1684-2267
이인옥(Lee, In Ok)
이정윤(Lee, Jung-Yun)
정영신(Chung, Young Shin)
조한별(Cho, Hanbyoul) ORCID logo https://orcid.org/0000-0002-6177-1648
채두병(Chay, Doo Byung) ORCID logo https://orcid.org/0000-0002-0648-4021
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161797
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