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Intracranial squamous cell carcinoma arising in a cerebellopontine angle epidermoid cyst: A case report and literature review.

Authors
 Tae Hoon Roh  ;  Yong Sook Park  ;  Yong Gou Park  ;  Se Hoon Kim  ;  Jong Hee Chang 
Citation
 Medicine, Vol.96(51) : e9423, 2017 
Journal Title
 Medicine 
ISSN
 0025-7974 
Issue Date
2017
MeSH
Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Cerebellar Neoplasms/diagnosis ; Cerebellar Neoplasms/etiology ; Cerebellar Neoplasms/pathology ; Cerebellar Neoplasms/therapy ; Cerebellopontine Angle*/pathology ; Combined Modality Therapy ; Epidermal Cyst/complications ; Female ; Humans ; Middle Aged
Abstract
RATIONALE: Most of the intracranial epidermoid cysts are benign, but malignant lesions are occasionally reported. These lesions appear as squamous cell carcinoma and carry a dismal prognosis. Here, we report a case of a primary intracranial squamous cell carcinoma arising in a cerebellopontine epidermoid cyst. The relevant literatures were also reviewed. PATIENT CONCERNS: A 53-year-old woman presented with dizziness and diplopia 9 months in duration. Magnetic resonance imaging revealed an epidermoid cyst in the left cerebellopontine angle and prepontine region with a focal enhancing lesion on T1-weighted gadolinium-enhanced images. DIAGNOSES: Histopathologic diagnosis revealed squamous cell carcinoma on a background of epidermoid cyst. Imaging studies excluded metastases. INTERVENTIONS: The tumor was removed subtotally through a lateral suboccipital approach. The patient received intensity modulated radiation therapy (6720 cGy total) postoperatively. OUTCOMES: The patient was free from recurrence of the tumor until 3 years after surgery, at which point she was lost to follow-up. The patient died 4 years after the surgery. LESSONS: The epidermoid cyst may occasionally become malignant. Finding an area of enhancement through preoperative magnetic resonance imaging can help to make a correct diagnosis. Based on the review of previous reports, surgical removal followed by radiotherapy shows the best result to treat malignant epidermoid cysts.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161725
DOI
10.1097/MD.0000000000009423
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
김세훈(Kim, Se Hoon) ; 박용구(Park, Yong Gou) ; 장종희(Chang, Jong Hee)
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