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Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Authors
 Daryeon Son  ;  Zhejiu Quan  ;  Phil Jun Kang  ;  Gyuman Park  ;  Hoon-Chul Kang  ;  Seungkwon You 
Citation
 STEM CELL RESEARCH, Vol.25 : 46-49, 2017 
Journal Title
 STEM CELL RESEARCH 
ISSN
 1873-5061 
Issue Date
2017
Abstract
X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.
Files in This Item:
T201705584.pdf Download
DOI
10.1016/j.scr.2017.10.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161695
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