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Identification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis

Authors
 Won Kyu Kim  ;  Yujin Kwon  ;  Minhee Park  ;  Seongju Yun  ;  Ja-Young Kwon  ;  Hoguen Kim 
Citation
 BMB REPORTS, Vol.50(11) : 590-595, 2017 
Journal Title
 BMB REPORTS 
ISSN
 1976-6696 
Issue Date
2017
Keywords
Angiogenesis ; Endothelial cell ; Gene expression profile ; HMGB-1 ; VEGF
Abstract
High-mobility group box-1 (HMGB-1) is expressed in almost all cells, and its dysregulated expression correlates with inflammatory diseases, ischemia, and cancer. Some of these conditions accompany HMGB-1-mediated abnormal angiogenesis. Thus far, the mechanism of HMGB-1-induced angiogenesis remains largely unknown. In this study, we performed time-dependent DNA microarray analysis of endothelial cells (ECs) after HMGB-1 or VEGF treatment. The pathway analysis of each gene set upregulated by HMGB-1 or VEGF showed that most HMGB-1-induced angiogenic pathways were also activated by VEGF, although the activation time and gene sets belonging to the pathways differed. In addition, HMGB-1 upregulated some VEGFR signaling-related angiogenic factors including EGR1 and, importantly, novel angiogenic factors, such as ABL2, CEACAM1, KIT, and VIPR1, which are reported to independently promote angiogenesis under physiological and pathological conditions. Our findings suggest that HMGB-1 independently induces angiogenesis by activating HMGB-1-specific angiogenic factors and also functions as an accelerator for VEGF-mediated conventional angiogenesis.
Files in This Item:
T201705263.pdf Download
DOI
10.5483/BMBRep.2017.50.11.129
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Won Kyu(김원규)
Kim, Ho Keun(김호근)
Park, Min Hee(박민희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161593
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