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Identification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis

DC FieldValueLanguage
dc.contributor.author권자영-
dc.contributor.author김원규-
dc.contributor.author김호근-
dc.contributor.author박민희-
dc.date.accessioned2018-07-20T11:59:24Z-
dc.date.available2018-07-20T11:59:24Z-
dc.date.issued2017-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161593-
dc.description.abstractHigh-mobility group box-1 (HMGB-1) is expressed in almost all cells, and its dysregulated expression correlates with inflammatory diseases, ischemia, and cancer. Some of these conditions accompany HMGB-1-mediated abnormal angiogenesis. Thus far, the mechanism of HMGB-1-induced angiogenesis remains largely unknown. In this study, we performed time-dependent DNA microarray analysis of endothelial cells (ECs) after HMGB-1 or VEGF treatment. The pathway analysis of each gene set upregulated by HMGB-1 or VEGF showed that most HMGB-1-induced angiogenic pathways were also activated by VEGF, although the activation time and gene sets belonging to the pathways differed. In addition, HMGB-1 upregulated some VEGFR signaling-related angiogenic factors including EGR1 and, importantly, novel angiogenic factors, such as ABL2, CEACAM1, KIT, and VIPR1, which are reported to independently promote angiogenesis under physiological and pathological conditions. Our findings suggest that HMGB-1 independently induces angiogenesis by activating HMGB-1-specific angiogenic factors and also functions as an accelerator for VEGF-mediated conventional angiogenesis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfBMB Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIdentification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Obstetrics & Gynecology-
dc.contributor.googleauthorWon Kyu Kim-
dc.contributor.googleauthorYujin Kwon-
dc.contributor.googleauthorMinhee Park-
dc.contributor.googleauthorSeongju Yun-
dc.contributor.googleauthorJa-Young Kwon-
dc.contributor.googleauthorHoguen Kim-
dc.identifier.doi10.5483/BMBRep.2017.50.11.129-
dc.contributor.localIdA00246-
dc.contributor.localIdA00764-
dc.contributor.localIdA01183-
dc.contributor.localIdA01471-
dc.relation.journalcodeJ00348-
dc.identifier.eissn1976-670X-
dc.identifier.pmid29065965-
dc.subject.keywordAngiogenesis-
dc.subject.keywordEndothelial cell-
dc.subject.keywordGene expression profile-
dc.subject.keywordHMGB-1-
dc.subject.keywordVEGF-
dc.contributor.alternativeNameKwon, Ja Young-
dc.contributor.alternativeNameKim, Won Kyu-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNamePark, Min Hee-
dc.contributor.affiliatedAuthorKwon, Ja Young-
dc.contributor.affiliatedAuthorKim, Won Kyu-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorPark, Min Hee-
dc.citation.volume50-
dc.citation.number11-
dc.citation.startPage590-
dc.citation.endPage595-
dc.identifier.bibliographicCitationBMB Reports, Vol.50(11) : 590-595, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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