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LEF1; TFE3; and AR are putative diagnostic markers of solid pseudopapillary neoplasms

Authors
 Eun Kyung Kim  ;  Mi Jang  ;  Minhee Park  ;  Hoguen Kim 
Citation
 Oncotarget, Vol.8(55) : 93404-93413, 2017 
Journal Title
 Oncotarget 
Issue Date
2017
Keywords
Ki-67 ; Pathology Section ; androgen receptor ; lymphoid enhancer-binding factor 1 ; solid pseudopapillary neoplasm ; transcription factor for immunoglobulin heavy-chain enhancer 3
Abstract
The diagnosis of solid pseudopapillary neoplasms (SPNs) is challenging because some SPNs share many similar morphological and immunohistochemical features with other pancreatic neoplasms. In this study, we investigated potential diagnostic markers of SPN. Based on the SPN-specific upregulated genes from a previous DNA microarray and proteome study, we selected six immunohistochemical markers [beta-catenin, androgen receptor (AR), lymphoid enhancer-binding factor 1 (LEF1), transcription factor for immunoglobulin heavy-chain enhancer 3 (TFE3), fused in sarcoma (FUS), and WNT inhibitory factor 1 (WIF-1)]. We also evaluated the Ki-67 proliferative index to investigate its associations with prognosis. To validate these markers, we studied 91 SPNs as well as 51 pancreatic ductal carcinomas (PDC) and 48 neuroendocrine tumors (NET) as controls. We found frequent and diffuse nuclear expressions of β-catenin (98.9%), AR (81.3%), LEF1 (93.4%), TFE3 (74.7%), FUS (84.6%), and cytoplasmic expression of WIF-1 (96.7%) in SPNs. In contrast, PDCs and NETs showed no expression. (P < 0.001). When beta-catenin, LEF1, and TFE3 staining were combined, the sensitivity and specificity were 100% and 91.9%, respectively. Four (4.4%) SPNs showed distant metastasis and these tumors were associated with a relatively high Ki-67 proliferative index (≥ 5%; P = 0.013). We identified LEF1, TFE3, and AR as putative diagnostic markers of SPN, auxiliary to β-catenin. Incorporated into an immunohistochemical panel, these markers could be beneficial to distinguish SPN from PDC and NET. In addition, we suggest that the Ki-67 proliferative index can be a predictive marker of metastasis in SPNs.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161591
DOI
10.18632/oncotarget.21854
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김은경(Kim, Eun Kyung)
김호근(Kim, Ho Keun)
박민희(Park, Min Hee)
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