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Validation of PAGE-B model in Asian chronic hepatitis B patients receiving entecavir or tenofovir.

Authors
 Mi Na Kim  ;  Seong Gyu Hwang  ;  Kyu Sung Rim  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kwang‐Hyub Han  ;  Seung Up Kim 
Citation
 Liver International, Vol.37(12) : 1788-1795, 2017 
Journal Title
 Liver International 
ISSN
 1478-3223 
Issue Date
2017
Keywords
PAGE-B ; chronic hepatitis B ; hepatocellular carcinoma ; risk prediction model
Abstract
BACKGROUND & AIMS: A new hepatocellular carcinoma risk prediction model, PAGE-B, which includes age, gender and platelet count as constituent variables, has recently been proposed in Caucasian chronic hepatitis B patients. We validated PAGE-B model and compared its accuracy with that of conventional risk prediction models in Asian chronic hepatitis B patients. METHODS: Chronic hepatitis B patients treated with entecavir or tenofovir were consecutively recruited. The performance of PAGE-B and three conventional risk prediction models (CU-HCC, GAG-HCC and REACH-B) were analysed. RESULTS: A total of 1092 chronic hepatitis B patients (668 men, 61.2%) were selected between August 2006 and January 2015. The mean age was 48 years. During the follow-up period (median, 43.6 months), 36 (3.3%) patients developed hepatocellular carcinoma. Older age (hazard ratio [HR]=1.077), male gender (HR=3.676) and lower platelet count (HR=0.984) were independent predictors of hepatocellular carcinoma development. The PAGE-B showed similar area under receiver operating characteristic curves (AUROCs) to GAG-HCC and CU-HCC at 3 years (0.777 vs 0.793 and 0.743, respectively; all P>.05) and 5 years (0.799 vs 0.803 and 0.744, respectively; all P>.05), whereas the AUROCs of PAGE-B were significantly higher than those of the REACH-B (0.602 at 3 years and 0.572 at 5 years, P<.05). CONCLUSIONS: Our study demonstrated that PAGE-B is applicable to Asian chronic hepatitis B patients receiving ETV or TDF therapy. The PAGE-B showed similar predictive performance to GAG-HCC and CU-HCC.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161576
DOI
10.1111/liv.13450
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김도영(Kim, Do Young) ; 김범경(Kim, Beom Kyung) ; 김승업(Kim, Seung Up) ; 박준용(Park, Jun Yong) ; 안상훈(Ahn, Sang Hoon) ; 한광협(Han, Kwang Hyup)
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Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/liv.13450
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