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Verification of Current Risk Scores for Kawasaki Disease in Korean Children

Authors
 Jaeeun Shin, Heeyoung Lee, and Lucy Eun 
Citation
 Journal of Korean Medical Science, Vol.32(12) : 1991-1996, 2017 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2017
MeSH
Age Factors ; Asian Continental Ancestry Group ; Aspartate Aminotransferases/blood ; Blood Platelets/cytology ; C-Reactive Protein/analysis ; Child, Preschool ; Drug Resistance ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant ; Male ; Mucocutaneous Lymph Node Syndrome/diagnosis* ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Multivariate Analysis ; Predictive Value of Tests ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Sex Factors
Keywords
Intravenous Immunoglobulin ; Kawasaki Disease ; Prediction ; Resistance ; Risk Score
Abstract
The purpose of this study was to evaluate and assess the compatibility of current risk scoring systems from Japan that were developed to predict intravenous immunoglobulin (IVIG) resistance in patients with Kawasaki disease (KD). The authors previously investigated another prediction model for patients with refractory KD in Korea. A retrospective study involving 350 patients with KD who were admitted between January 2014 and December 2015 was performed. Patients younger than 2 years were excluded for the propensity score matching in this study. Patients were classified into IVIG responders and IVIG resistance groups. The well-known Harada, Kobayashi, and Egami risk scores were calculated for each patient, and the proportion of high-risk patients was compared between the two groups for each risk score. Logistic regression analysis revealed that platelets, C-reactive protein (CRP) levels, and aspartate aminotransferase levels were independent predictors of IVIG resistance. Multivariate analysis suggested that platelets and CRP were risk factors. Risk-scoring systems from Japan have good specificity but low sensitivity. Among the three risk scoring systems, the Kobayashi risk score demonstrated significant differences between the IVIG resistance and IVIG responder groups in Korean patients with KD. It is very important to identify IVIG-resistant patients to protect them from ongoing coronary arterial lesion(s); therefore, early prediction and timely optimal additional treatment is of significant benefit. It would be helpful to construct a highly sensitive, exclusive scoring system for Korean patients with KD.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161545
DOI
10.3346/jkms.2017.32.12.1991
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
은영민(Eun, Young Min)
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