Cited 18 times in
Associations of changes in body mass index with all-cause and cardiovascular mortality in healthy middle-aged adults.
DC Field | Value | Language |
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dc.contributor.author | 김현창 | - |
dc.contributor.author | 성지민 | - |
dc.contributor.author | 장혁재 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 조인정 | - |
dc.date.accessioned | 2018-07-20T11:56:54Z | - |
dc.date.available | 2018-07-20T11:56:54Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161534 | - |
dc.description.abstract | BACKGROUND: Conflicting data exist regarding the association of body mass index (BMI) changes with all-cause and cardiovascular (CV) mortality. The current study investigated the association between changes in BMI and all-cause, CV, and non-CV mortality in a large cohort of middle-aged adults. METHODS: A total of 379,535 adults over 40 years of age without pre-existing CV disease or cancer at baseline were enrolled to undergo a series of at least three health examinations of biennial intervals. Changes in BMI between baseline, midpoint follow-up, and final health examination during mean 9.3 years were defined according to the pattern of BMI change as follows: stable, sustained gain, sustained loss, and fluctuation. The relationship between BMI change category and mortality was assessed by multivariate Cox regression reporting hazard ratio (HR) with 95% confidence interval (95% CI). RESULTS: During a mean follow-up of 10.7 years for mortality, 12,378 deaths occurred from all causes, of which 2,114 were CV and 10,264 were non-CV deaths. Sustained BMI gain was associated with the lower risk of all-cause (HR 0.89, 95% CI: 0.83-0.95), CV (HR 0.84, 95% CI 0.72-0.98), and non-CV mortality (HR 0.90, 95% CI 0.84-0.96) compared with stable BMI. Conversely, sustained BMI loss (HR 1.25, 95% CI 1.19-1.32) and fluctuation (HR 1.13, 95% CI 1.08-1.19) displayed a higher risk of all-cause mortality compared with stable BMI, which was mainly attributable to the increase in non-CV mortality. CONCLUSION: Sustained BMI gains were associated with reduced risk of all-cause, CV, and non-CV mortality in middle-aged healthy adults. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Body Mass Index* | - |
dc.subject.MESH | Cardiovascular Diseases/mortality* | - |
dc.subject.MESH | Cardiovascular Diseases/pathology* | - |
dc.subject.MESH | Cause of Death* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.title | Associations of changes in body mass index with all-cause and cardiovascular mortality in healthy middle-aged adults. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | In-Jeong Cho | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Ji Min Sung | - |
dc.contributor.googleauthor | Young Mi Yun | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.identifier.doi | 10.1371/journal.pone.0189180 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A01955 | - |
dc.contributor.localId | A03490 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A03892 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 29216261 | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.alternativeName | Sung, Ji Min | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Cho, In Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | Sung, Ji Min | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Cho, In Jeong | - |
dc.citation.volume | 12 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | e0189180 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.12(12) : e0189180, 2017 | - |
dc.identifier.rimsid | 61565 | - |
dc.type.rims | ART | - |
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