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Clinical implications of the plasma EphA2 receptor level in critically ill patients with septic shock

Authors
 Su Hwan Lee  ;  Ju Hye Shin  ;  Joo Han Song  ;  Ah Young Leem  ;  Moo Suk Park  ;  Young Sam Kim  ;  Joon Chang  ;  Kyung Soo Chung 
Citation
 Scientific Reports, Vol.7(1) : 17612, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
The Eph/ephrin receptor ligand system is known to play a role in inflammation induced by infection, injury, and inflammatory diseases. The present study aimed to evaluate plasma EphA2 receptor levels in critically ill patients with sepsis. This study was a prospective cohort study evaluating samples and clinical data from the medical intensive care unit (MICU) of a 2000-bed university tertiary referral hospital in South Korea. Positive correlations of the plasma EphA2 receptor level with the acute physiology and chronic health evaluation (APACHE) II score and the sequential organ failure assessment (SOFA) score were observed. The area under the curve (AUC) for the plasma EphA2 receptor level on a receiver operating characteristic curve was 0.690 (95% confidence interval [CI], 0.608-0.764); the AUCs for the APACHE II score and SOFA scores were 0.659 (95% CI, 0.576-0.736) and 0.745 (95% CI, 0.666-0.814), respectively. A Cox proportional hazard model identified an association between an increased plasma EphA2 receptor level (>51.5 pg mL-1) and increased risk of 28-day mortality in the MICU (hazard ratio = 3.22, 95% CI, 1.709-6.049). An increased plasma EphA2 receptor level was associated with sepsis severity and 28-day mortality among sepsis patients.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161505
DOI
10.1038/s41598-017-17909-7
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김영삼(Kim, Young Sam) ; 박무석(Park, Moo Suk) ; 송주한(Song, Joo Han) ; 임아영(Leem, Ah Young) ; 장준(Chang, Joon) ; 정경수(Jung, Kyung Soo)
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