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Predictors of health-related quality of life in Korean prostate cancer patients receiving androgen deprivation therapy

Authors
 Soo Hyun Kim  ;  Do Hwan Seong  ;  Sang Min Yoon  ;  Young Deuk Choi  ;  Eunju Choi  ;  Hosook Song 
Citation
 European Journal of Oncology Nursing, Vol.30 : 84-90, 2017 
Journal Title
 European Journal of Oncology Nursing 
ISSN
 1462-3889 
Issue Date
2017
MeSH
Adult ; Aged ; Aged, 80 and over ; Androgen Antagonists/therapeutic use* ; Anxiety/psychology ; Asian Continental Ancestry Group/psychology* ; Asian Continental Ancestry Group/statistics & numerical data* ; Comorbidity ; Cross-Sectional Studies ; Depression/psychology ; Fatigue/psychology ; Humans ; Male ; Middle Aged ; Prevalence ; Prostatic Neoplasms/drug therapy* ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/psychology* ; Quality of Life/psychology* ; Republic of Korea/epidemiology ; Surveys and Questionnaires
Keywords
Anxiety ; Depression ; Fatigue ; Prostatic neoplasm ; Quality of life
Abstract
PURPOSE: We aimed to examine the level of psychological distress, fatigue, and health-related quality of life (HRQOL) and identify HRQOL predictors in men with prostate cancer receiving androgen deprivation therapy (ADT). METHODS: Using a cross-sectional design, we recruited 161 men with prostate cancer receiving ADT (mean age, 73 years) at two university-based hospitals in South Korea. Participants completed a self-reported questionnaire. Measures included the Hospital Anxiety and Depression Scale (HADS), the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) subscale, and the Functional Assessment of Cancer Therapy-Prostate (FACT-P). RESULTS: The mean scores were 3.3 (SD = 2.8) for anxiety with a prevalence of 8.9%, 5.7 (SD = 3.8) for depression with a prevalence of 25.5%, and 30.3 (SD = 7.4) for fatigue with a prevalence of 15.6%. The five FACT-P subscale means were 23.9 (SD = 4.3) for physical well-being, 15.4 (SD = 6.4) for social well-being, 18.5 (SD = 4.3) for emotional well-being, 17.3 (SD = 5.6) for functional well-being, and 30.3 (SD = 7.4) for the prostate cancer-specific subscale. Multiple linear regression analysis revealed that depression, which was inversely associated with all FACT-P subscales, was the strongest predictor of worse HRQOL. Fatigue and comorbid conditions were also associated with the HRQOL of multiple domains. CONCLUSION: This study suggests that intervention aimed at improving HRQOL of men receiving ADT should include depression, fatigue, and comorbidity management.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161492
DOI
10.1016/j.ejon.2017.08.009
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실)
Yonsei Authors
최영득(Choi, Young Deuk)
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Full Text
https://www.sciencedirect.com/science/article/pii/S1462388917301977
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