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Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK)

Authors
 Jung-Hwan Baek  ;  Nam-Jun Kim  ;  Jun-Kyu Song  ;  Kyung-Hee Chun 
Citation
 BMB Reports, Vol.50(11) : 566-571, 2017 
Journal Title
 BMB Reports 
ISSN
 1976-6696 
Issue Date
2017
Keywords
Adipogenesis ; AMPK ; Coffee bean ; Glucose-uptake ; Kahweol
Abstract
Weight loss ≥ 5 percent is sufficient to significantly reduce health risks for obese people; therefore, development of novel weight loss compounds with reduced toxicity is urgently required. After screening of natural compounds with antiadipogenesis properties in 3T3-L1 cells, we determined that kahweol, a coffee-specific diterpene, inhibited adipogenesis. Kahweol reduced lipid accumulation and expression levels of adipogenesis and lipid accumulation-related factors. Levels of phosphorylated AKT and phosphorylated JAK2, that induce lipid accumulation, decreased in kahweol-treated cells. Particularly, kahweol treatment significantly increased AMP-activated protein kinase (AMPK) activation. We revealed that depletion of AMPK alleviated reduction in lipid accumulation from kahweol treatment, suggesting that inhibition of lipid accumulation by kahweol is dependent on AMPK activation. We detected more rapid reduction in blood glucose levels in mice administrated kahweol than in control mice. We suggest that kahweol has anti-obesity effects and should be studied further for possible therapeutic applications.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161447
DOI
10.5483/BMBRep.2017.50.11.031
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
Yonsei Authors
백정환(Baek, Jung Hwan) ; 전경희(Chun, Kyung Hee)
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