Cited 8 times in
Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2018-07-20T11:52:42Z | - |
dc.date.available | 2018-07-20T11:52:42Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161440 | - |
dc.description.abstract | In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the size was reduced for rapid entry into lymphatic vessels, and the immunologically inert nanomicelles were turned into potential activators of inflammasomes. Aminated γ-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1β. The NLRP3-dependent inflammasome induction mechanism was confirmed through enzyme (cathepsin B and caspase-1) inhibitors and NLRP3 knockout mice model. After the aPNMs were combined with a clinically evaluated TLR3 agonist, polyinosinic-polycytidylic acid sodium salt (aPNM-IC), they triggered multiple arms of the innate immune response, including the secretion of pro-inflammatory cytokines by both inflammasomes and an inflammasome-independent pathway and the included type I interferons. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | DOVE Medical Press | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adjuvants, Immunologic/pharmacology* | - |
dc.subject.MESH | Amines/chemistry* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Caspase 1/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Immunity, Innate*/drug effects | - |
dc.subject.MESH | Inflammasomes/metabolism* | - |
dc.subject.MESH | Lymph Nodes/drug effects | - |
dc.subject.MESH | Lymph Nodes/immunology* | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Micelles* | - |
dc.subject.MESH | NLR Family, Pyrin Domain-Containing 3 Protein/metabolism | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Poly I-C/pharmacology | - |
dc.subject.MESH | Polyglutamic Acid/analogs & derivatives | - |
dc.subject.MESH | Polyglutamic Acid/chemistry | - |
dc.subject.MESH | Vaccines/immunology* | - |
dc.title | Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Chanyoung Song | - |
dc.contributor.googleauthor | #1 | - |
dc.contributor.googleauthor | * Hathaichanok Phuengkham | - |
dc.contributor.googleauthor | #1 | - |
dc.contributor.googleauthor | * Sun-Young Kim | - |
dc.contributor.googleauthor | 1 Min Sang Lee | - |
dc.contributor.googleauthor | 2 Ji Hoon Jeong | - |
dc.contributor.googleauthor | 2 Sung Jae Shin | - |
dc.contributor.googleauthor | 3 and Yong Taik Lim | - |
dc.identifier.doi | 10.2147/IJN.S144623 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01134 | - |
dc.identifier.eissn | 1178-2013 | - |
dc.identifier.pmid | 29066896 | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 7501 | - |
dc.citation.endPage | 7517 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, Vol.12 : 7501-7517, 2017 | - |
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