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Hepatitis C virus p7 induces mitochondrial depolarization of isolated liver mitochondria

Authors
 You Deok Gyun  ;  Lee Hye Ra  ;  Kim Won Ki  ;  Kim Hyung Jung  ;  Lee Gi Young 
Citation
 MOLECULAR MEDICINE REPORTS, Vol.16(6) : 9533-9538, 2017 
Journal Title
MOLECULAR MEDICINE REPORTS
ISSN
 1791-2997 
Issue Date
2017
Abstract
Hepatitis C virus (HCV)‑encoded protein p7 is a viroporin that acts as an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria. HCV‑infected cells show mitochondrial depolarization and ATP depletion; however, the function of HCV p7 in mitochondria is not fully understood. The present study demonstrated that treatment of isolated mouse liver mitochondria with the synthesized HCV p7 protein induced mitochondrial dysfunction. It also demonstrated that HCV p7 targeted isolated mouse liver mitochondria and induced mitochondrial depolarization. In addition, HCV p7 triggered matrix acidification and, ultimately, a decrease in ATP synthesis in isolated mitochondria. These findings indicate that targeting of mitochondria by HCV p7 in infected cells causes mitochondrial dysfunction to support HCV particle production. The present study provided evidence for the role of HCV p7 in mitochondria, and may lead to the development of novel strategies for HCV therapy.
Full Text
https://search.proquest.com/docview/1986671164?accountid=15179
DOI
10.3892/mmr.2017.7809
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161428
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