Cited 4 times in
Dose de-escalation to the normal larynx using conformal radiotherapy reduces toxicity while maintaining oncologic outcome for T1/T2 glottic cancer
DC Field | Value | Language |
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dc.contributor.author | 김준원 | - |
dc.contributor.author | 변형권 | - |
dc.contributor.author | 이익재 | - |
dc.contributor.author | 최홍식 | - |
dc.date.accessioned | 2018-07-20T08:47:55Z | - |
dc.date.available | 2018-07-20T08:47:55Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161398 | - |
dc.description.abstract | We evaluated the efficacy of dose de-escalation to the normal larynx using conformal radiotherapy (CRT) for T1/T2 glottic cancer. For conventional RT (2DRT, n = 38), the laryngeal box received a median equivalent dose in 2 Gy fractions (EQD2) of 66 Gy. For CRT (n = 42; 3D-CRT, 20; intensity-modulated RT, 22), clinical target volume (CTV)1 (gross tumor with a 3-mm margin) and CTV2 (laryngeal box) received median EQD2s of 66.6 Gy and 52.2 Gy, respectively. With a 71-month median follow-up, five-year local control and overall survival rates for 2DRT vs. CRT were 88.1% vs. 95.1% (p = 0.405) and 94.7% vs. 90.7% (p = 0.102), respectively. Grade 2 and 3 pharyngitis rates were 52.6% and 5.3% for 2DRT vs. 35.7% and 2.4% for CRT (p = 0.121). Grade 2 and 3 dermatitis rates were 42.1% and 2.6% for 2DRT vs. 35.7% and 0% for CRT (p = 0.013). The maximum phonation time increased from 12.1 ± 7.1 to 14.0 ± 6.6 seconds after 2DRT (p = 0.375) and from 12.0 ± 5.5 to 13.8 ± 10.1 seconds after CRT (p = 0.313). Fundamental frequency decreased from 150.6 ± 40.3 to 121.9 ± 30.2 Hz after 2DRT (p = 0.039) and from 138.5 ± 31.9 to 126.1 ± 23.7 Hz after CRT (p = 0.058). CRT can effectively de-escalate the normal larynx dose while maintaining oncologic outcome and voice quality. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Dose de-escalation to the normal larynx using conformal radiotherapy reduces toxicity while maintaining oncologic outcome for T1/T2 glottic cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.contributor.googleauthor | Hyung Kwon Byeon | - |
dc.contributor.googleauthor | Hong-Shik Choi | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.identifier.doi | 10.1038/s41598-017-15974-6 | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A01862 | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A04223 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 29147004 | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.alternativeName | Byeon, Hyung Kwon | - |
dc.contributor.alternativeName | Lee, Ik Jae | - |
dc.contributor.alternativeName | Choi, Hong Shik | - |
dc.contributor.affiliatedAuthor | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | Byeon, Hyung Kwon | - |
dc.contributor.affiliatedAuthor | Lee, Ik Jae | - |
dc.contributor.affiliatedAuthor | Choi, Hong Shik | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 15732 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.7(1) : 15732, 2017 | - |
dc.identifier.rimsid | 61316 | - |
dc.type.rims | ART | - |
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