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Quality of life on TSU-68: Combination of docetaxel and TSU-68, an oral antiangiogenic agent, in patients with metastatic breast cancer previously treated with anthracycline

Authors
 Byeong Seok Sohn  ;  Sung‐Bae Kim  ;  Jin‐Hee Ahn  ;  Kyung Hae Jung  ;  Jeongeun Kim  ;  Keun Seok Lee  ;  Jungsil Ro  ;  Seock‐Ah Im  ;  Young‐Hyuck Im  ;  Hong Suk Song  ;  Hee Sook Park  ;  Hyun‐Cheol Chung 
Citation
 Asia-Pacific Journal of Clinical Oncology, Vol.13(6) : 365-371, 2017 
Journal Title
 Asia-Pacific Journal of Clinical Oncology 
ISSN
 1743-7555 
Issue Date
2017
Keywords
TSU-68 ; breast cancer ; docetaxel ; quality of life
Abstract
AIM: The aim of this study is to investigate whether the addition of TSU-68 would affect on the quality of life (QOL) of Korean metastatic breast cancer patients treated with docetaxel. METHODS: Sixty-three of 78 patients completed the baseline QOL questionnaires and at least one follow-up questionnaire comprising questions from the Korean Functional Assessment of Cancer Therapy-Breast (FACT-B), hospital anxiety and depression scale (HAD), the shortened form of the profile of mood states (BPOMS), and anticipation and anxiety for treatment scale. Changes in QOL scores from baseline were compared by analysis of covariance at each time point (6, 12 weeks, 9, 12 and 18 months) and at the end of treatment (EOT), and the longitudinal changes over time were evaluated by repeated measure analysis. RESULTS: The two-treatment groups (TSU-68 plus docetaxel [A] vs docetaxel alone [B]) were well balanced regarding sociodemographic characteristics, including age (P = 0.450), religion (P = 1.000), education (P = 0.257), ECOG performance status (P = 0.261), and employment status (P = 0.325). The return rate at EOT was 61.9%. In analyses at each QOL measuring time, A group showed a higher FACT-B total score and FACT-G score than B at 12 months (P = 0.031 and P = 0.024, respectively). The anticipation and anxiety for treatment scale of A group was higher than that of B at 12 weeks and EOT (P = 0.046 and P = 0.022, respectively). However, repeated measure analysis for longitudinal changes over time showed no significant group wise differences. CONCLUSIONS: The combination of TSU-68 with docetaxel showed no additional adverse effects on patient QOL during the study period, as compared with docetaxel monotherapy.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/ajco.12681
DOI
10.1111/ajco.12681
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161356
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