Cited 11 times in
Effects of remote ischemic preconditioning in patients with concentric myocardial hypertrophy: A randomized, controlled trial with molecular insights
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 송영 | - |
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 이삭 | - |
dc.contributor.author | 전지혜 | - |
dc.date.accessioned | 2018-07-20T08:39:29Z | - |
dc.date.available | 2018-07-20T08:39:29Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161347 | - |
dc.description.abstract | BACKGROUND: Efficacy of remote ischemic preconditioning (RIPC) for cardioprotection in cardiac surgery is controversial. We aimed to evaluate the clinical and molecular effects of RIPC on the concentrically hypertrophied myocardium. METHODS: Seventy-two aortic stenosis patients receiving aortic valve replacement (AVR) under sevoflurane anesthesia were randomly allocated to RIPC (3cycles of 5-min inflation [300mmHg] and deflation on the left arm) or control (deflated cuff placement) group. The primary endpoints were 24-h area under the curve (AUC) for serum creatine kinase (CK)-MB and troponin (Tn)-T levels. The secondary endpoints were myocardial activation of cell signaling pathways, including reperfusion injury salvage kinases (RISK), signal transducer and activator of transcription (STAT), nitric oxide synthase (NOS), and apoptosis related molecules, obtained from right atrial tissue before and after cardiopulmonary bypass (CPB). RESULTS: There were no intergroup differences in 24-h AUCs of CK-MB and Tn-T. Phosphorylations of RISK pathway molecules were not enhanced by RIPC before and after CPB. Phosphorylation of STAT5 was significantly lower in the RIPC group before and after CPB. Phosphorylations of STAT3 and endothelial NOS were not enhanced by RIPC before and after CPB. Expression level of cleaved caspases-3/caspase-3 was significantly higher in the RIPC group before CPB. CONCLUSIONS: RIPC did not provide clinical benefits or activate protective signaling in patients with concentric left ventricular hypertrophy undergoing AVR. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of remote ischemic preconditioning in patients with concentric myocardial hypertrophy: A randomized, controlled trial with molecular insights | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Young Song | - |
dc.contributor.googleauthor | Jong Wook Song | - |
dc.contributor.googleauthor | Sak Lee | - |
dc.contributor.googleauthor | Ji-Hae Jun | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.identifier.doi | 10.1016/j.ijcard.2017.08.073 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A02036 | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A02807 | - |
dc.relation.journalcode | J01093 | - |
dc.identifier.eissn | 1874-1754 | - |
dc.identifier.pmid | 28893433 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0167527317316078 | - |
dc.subject.keyword | Cardiac enzyme | - |
dc.subject.keyword | Cardiac surgery | - |
dc.subject.keyword | Intracellular signaling | - |
dc.subject.keyword | Left ventricular hypertrophy | - |
dc.subject.keyword | Remote ischemic preconditioning | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Song, Young | - |
dc.contributor.alternativeName | Song, Jong Wook | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Lee, Sak | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Song, Young | - |
dc.contributor.affiliatedAuthor | Song, Jong Wook | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Lee, Sak | - |
dc.citation.volume | 249 | - |
dc.citation.startPage | 36 | - |
dc.citation.endPage | 41 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.249 : 36-41, 2017 | - |
dc.identifier.rimsid | 61266 | - |
dc.type.rims | ART | - |
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