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Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds

DC Field Value Language
dc.contributor.author문석준-
dc.contributor.author정용택-
dc.date.accessioned2018-07-20T08:38:53Z-
dc.date.available2018-07-20T08:38:53Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161341-
dc.description.abstractAnimals must detect aversive compounds to survive. Bitter taste neurons express heterogeneous combinations of bitter receptors that diversify their response profiles, but this remains poorly understood. Here we describe groups of taste neurons in Drosophila that detect the same bitter compounds using unique combinations of gustatory receptors (GRs). These distinct complexes also confer responsiveness to non-overlapping sets of additional compounds. While either GR32a/GR59c/GR66a or GR22e/GR32a/GR66a heteromultimers are sufficient for lobeline, berberine, and denatonium detection, only GR22e/GR32a/GR66a responds to strychnine. Thus, despite minimal sequence-similarity, Gr22e and Gr59c show considerable but incomplete functional overlap. Since the gain- or loss-of-function of Gr22e or Gr59c alters bitter taste response profiles, we conclude a taste neuron's specific combination of Grs determines its response profile. We suspect the heterogeneity of Gr expression in Drosophila taste neurons diversifies bitter compound detection, improving animal fitness under changing environmental conditions that present a variety of aversive compounds.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHeterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorHa Yeon Sung-
dc.contributor.googleauthorYong Taek Jeong-
dc.contributor.googleauthorJi Yeon Lim-
dc.contributor.googleauthorHyeyon Kim-
dc.contributor.googleauthorSoo Min Oh-
dc.contributor.googleauthorSun Wook Hwang-
dc.contributor.googleauthorJae Young Kwon-
dc.contributor.googleauthorSeok Jun Moon-
dc.identifier.doi10.1038/s41467-017-01639-5-
dc.contributor.localIdA01358-
dc.contributor.localIdA03663-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid29133786-
dc.contributor.alternativeNameMoon, Seok Jun-
dc.contributor.alternativeNameJeong, Yong Taek-
dc.contributor.affiliatedAuthorMoon, Seok Jun-
dc.contributor.affiliatedAuthorJeong, Yong Taek-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage1484-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.8(1) : 1484, 2017-
dc.identifier.rimsid61260-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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