Cited 45 times in
Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문석준 | - |
dc.contributor.author | 정용택 | - |
dc.date.accessioned | 2018-07-20T08:38:53Z | - |
dc.date.available | 2018-07-20T08:38:53Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161341 | - |
dc.description.abstract | Animals must detect aversive compounds to survive. Bitter taste neurons express heterogeneous combinations of bitter receptors that diversify their response profiles, but this remains poorly understood. Here we describe groups of taste neurons in Drosophila that detect the same bitter compounds using unique combinations of gustatory receptors (GRs). These distinct complexes also confer responsiveness to non-overlapping sets of additional compounds. While either GR32a/GR59c/GR66a or GR22e/GR32a/GR66a heteromultimers are sufficient for lobeline, berberine, and denatonium detection, only GR22e/GR32a/GR66a responds to strychnine. Thus, despite minimal sequence-similarity, Gr22e and Gr59c show considerable but incomplete functional overlap. Since the gain- or loss-of-function of Gr22e or Gr59c alters bitter taste response profiles, we conclude a taste neuron's specific combination of Grs determines its response profile. We suspect the heterogeneity of Gr expression in Drosophila taste neurons diversifies bitter compound detection, improving animal fitness under changing environmental conditions that present a variety of aversive compounds. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral Biology | - |
dc.contributor.googleauthor | Ha Yeon Sung | - |
dc.contributor.googleauthor | Yong Taek Jeong | - |
dc.contributor.googleauthor | Ji Yeon Lim | - |
dc.contributor.googleauthor | Hyeyon Kim | - |
dc.contributor.googleauthor | Soo Min Oh | - |
dc.contributor.googleauthor | Sun Wook Hwang | - |
dc.contributor.googleauthor | Jae Young Kwon | - |
dc.contributor.googleauthor | Seok Jun Moon | - |
dc.identifier.doi | 10.1038/s41467-017-01639-5 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A03663 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 29133786 | - |
dc.contributor.alternativeName | Moon, Seok Jun | - |
dc.contributor.alternativeName | Jeong, Yong Taek | - |
dc.contributor.affiliatedAuthor | Moon, Seok Jun | - |
dc.contributor.affiliatedAuthor | Jeong, Yong Taek | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1484 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.8(1) : 1484, 2017 | - |
dc.identifier.rimsid | 61260 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.