18 22

Cited 0 times in

The recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation

Authors
 Juhan Lee  ;  Seung Hwan Song  ;  Jee Youn Lee  ;  Deok Gie Kim  ;  Jae Geun Lee  ;  Beom Seok Kim  ;  Myoung Soo Kim  ;  Kyu Ha Huh 
Citation
 Scientific Reports, Vol.7(1) : 13725, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
The effect of delayed graft function (DGF) recovery on long-term graft outcome is unclear. The aim of this study was to examine the association of DGF recovery status with long-term outcome. We analyzed 385 recipients who underwent single kidney transplantation from brain-dead donors between 2004 and 2015. Patients were grouped according to renal function at 1 month post-transplantation: control (without DGF); recovered DGF (glomerular filtration rate [GFR] ≥ 30 mL/min/1.73 m2); and incompletely recovered DGF group (GFR < 30 mL/min/1.73 m2). DGF occurred in 104 of 385 (27%) recipients. Of the DGF patients, 70 recovered from DGF and 34 incompletely recovered from DGF. Death-censored graft survival rates for control, recovered DGF, and incompletely recovered DGF groups were 95.3%, 94.7%, and 80.7%, respectively, at 5 years post-transplantation (P = 0.003). Incompletely recovered DGF was an independent risk factor for death-censored graft loss (HR = 3.410, 95%CI, 1.114-10.437). DGF was associated with increased risk for patient death regardless of DGF recovery status. Mean GFRs at 5 years were 65.5 ± 20.8, 62.2 ± 27.0, and 45.8 ± 15.4 mL/min/1.73 m2 for control, recovered, and incompletely recovered DGF groups, respectively (P < 0.001). Control group and recovered DGF patients had similar renal outcomes. However, DGF was associated with increased risk for patient death regardless of DGF recovery status.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161339
DOI
10.1038/s41598-017-14154-w
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
Yonsei Authors
김덕기(Kim, Deok Gie) ; 김명수(Kim, Myoung Soo) ; 김범석(Kim, Beom Seok) ; 송승환(Song, Seung Hwan) ; 이재근(Lee, Jae Geun) ; 이주한(Lee, Ju Han) ; 이지연(Lee, Jee Youn) ; 허규하(Huh, Kyu Ha)
사서에게 알리기
  feedback
Files in This Item:
T201704606.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse