Cited 27 times in
Subcortical shape analysis of progressive mild cognitive impairment in Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | 손영호 | - |
dc.contributor.author | 이윤주 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 조규호 | - |
dc.date.accessioned | 2018-07-20T08:38:14Z | - |
dc.date.available | 2018-07-20T08:38:14Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0885-3185 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161338 | - |
dc.description.abstract | BACKGROUND: Cortical neural correlates of ongoing cognitive decline in Parkinson's disease (PD) have been suggested; however, the role of subcortical structures in longitudinal change of cognitive dysfunction in PD has not been fully investigated. Here, we used automatic analysis to explore subcortical brain structures in patients with PD with mild cognitive impairment that converts into PD with dementia. METHODS: One hundred eighty-two patients with PD with mild cognitive impairment were classified as PD with mild cognitive impairment converters (n = 74) or nonconverters (n = 108), depending on whether they were subsequently diagnosed with dementia in PD. We used surface-based analysis to compare atrophic changes of subcortical brain structures between PD with mild cognitive impairment converters and nonconverters. RESULTS: PD with mild cognitive impairment converters had lower cognitive composite scores in the attention and frontal executive domains than did nonconverters. Subcortical shape analysis revealed that PD with mild cognitive impairment converters had smaller local shape volumes than did nonconverters in the bilateral thalamus, right caudate, and right hippocampus. Logistic regression analysis showed that local shape volumes in the bilateral thalamus and right caudate were significant independent predictors of PD with mild cognitive impairment converters. In the PD with mild cognitive impairment converter group, thalamic local shape volume was associated with semantic fluency and attentional composite score. CONCLUSIONS: The present data suggest that the local shape volumes of deep subcortical structures, especially in the caudate and thalamus, may serve as important predictors of the development of dementia in patients with PD. © 2017 International Parkinson and Movement Disorder Society. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | MOVEMENT DISORDERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Attention | - |
dc.subject.MESH | Brain/diagnostic imaging | - |
dc.subject.MESH | Cognition Disorders/diagnostic imaging | - |
dc.subject.MESH | Cognition Disorders/etiology | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Executive Function | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Processing, Computer-Assisted | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mental Status Schedule | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Parkinson Disease/complications | - |
dc.subject.MESH | Parkinson Disease/diagnostic imaging | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.title | Subcortical shape analysis of progressive mild cognitive impairment in Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Su Jin Chung | - |
dc.contributor.googleauthor | Jeong‐Hyeon Shin | - |
dc.contributor.googleauthor | Kyoo Ho Cho | - |
dc.contributor.googleauthor | Yoonju Lee | - |
dc.contributor.googleauthor | Young H. Sohn | - |
dc.contributor.googleauthor | Joon‐Kyung Seong | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.1002/mds.27106 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A03024 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04668 | - |
dc.contributor.localId | A03811 | - |
dc.relation.journalcode | J02275 | - |
dc.identifier.eissn | 1531-8257 | - |
dc.identifier.pmid | 28737237 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/mds.27106 | - |
dc.subject.keyword | MCI converter | - |
dc.subject.keyword | MRI | - |
dc.subject.keyword | Parkinson's disease | - |
dc.subject.keyword | subcortical volume | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.alternativeName | Lee, Yoon Ju | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.alternativeName | Chung, Su Jin | - |
dc.contributor.alternativeName | Cho, Kyoo Ho | - |
dc.contributor.affiliatedAuthor | Sohn, Young Ho | - |
dc.contributor.affiliatedAuthor | Lee, Yoon Ju | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Chung, Su Jin | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Ho | - |
dc.citation.volume | 32 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1447 | - |
dc.citation.endPage | 1456 | - |
dc.identifier.bibliographicCitation | MOVEMENT DISORDERS, Vol.32(10) : 1447-1456, 2017 | - |
dc.identifier.rimsid | 61257 | - |
dc.type.rims | ART | - |
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