Cited 17 times in
Localized bone regeneration around dental implants using recombinant bone morphogenetic protein-2 and platelet-derived growth factor-BB in the canine
DC Field | Value | Language |
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dc.contributor.author | 정의원 | - |
dc.contributor.author | 차재국 | - |
dc.date.accessioned | 2018-07-20T08:36:23Z | - |
dc.date.available | 2018-07-20T08:36:23Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0905-7161 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161318 | - |
dc.description.abstract | OBJECTIVES: To test whether or not one of two biological mediators (recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor (rhPDGF-BB)) is superior to the other and compared with control groups for bone regeneration around implants based on histomorphometrical outcome measures. MATERIALS AND METHODS: Box-type defects (10 × 5 × 5 mm) were prepared on the buccal sides of the left and right edentulous ridge in ten mongrel dogs. Implants were placed at each site, the defects either received (i) bovine-derived particulated bone mineral (DBBM) mixed with rhBMP-2 and a collagen membrane (CM) (DBBM/BMP-2), (ii) DBBM mixed with rhPDGF-BB and CM (DBBM/PDGF), (iii) DBBM and CM (DBBM) and (iv) empty control (control). Animals were euthanized post-surgery at 8 weeks and 16 weeks. Histomorphometrical analyses were performed. RESULTS: The mean percentages of regenerated area within total defect area amounted to 56.95% for DBBM/BMP-2, 48.86% for DBBM/PDFG, 33.44% for DBBM and 1.59% for control at 8 weeks, and 26.79% for DBBM/BMP-2, 23.78% for DBBM/PDFG, 30.21% for DBBM and 5.07% for control at 16 weeks with no statistically significant differences between the groups (P > 0.05). The mean amount of regenerated bone was 26.97% for DBBM/BMP-2, 22.02% for DBBM/PDFG, 5.03% for DBBM and 1.25% for control at 8 weeks, and at 16 weeks, these values were lower in the two groups with biological mediators (DBBM/BMP-2 = 13.35%; DBBM/PDGF = 6.96%) and only slightly increased in group DBBM (10.68%) and the control group (4.95%) compared with 8 weeks. The first bone-to-implant contact values on the buccal side were minimal for DBBM/BMP-2 (0.57 mm) and maximal for control (3.72 mm) at 8 weeks. CONCLUSIONS: The use of biological mediators (rhBMP-2 and rhPDGF-BB) can increase the amount of bone regeneration at dehiscence-type defects compared with controls at 8 weeks, but not at 16 weeks due to enhanced hard tissue remodeling processes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | John Wiley and Sons, Inc. | - |
dc.relation.isPartOf | CLINICAL ORAL IMPLANTS RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Localized bone regeneration around dental implants using recombinant bone morphogenetic protein-2 and platelet-derived growth factor-BB in the canine | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Periodontology | - |
dc.contributor.googleauthor | Daniel S. Thoma | - |
dc.contributor.googleauthor | Jae‐Kook Cha | - |
dc.contributor.googleauthor | Vitor M. Sapata | - |
dc.contributor.googleauthor | Ronald E. Jung | - |
dc.contributor.googleauthor | Juerg Hüsler | - |
dc.contributor.googleauthor | Ui‐Won Jung | - |
dc.identifier.doi | 10.1111/clr.12989 | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A04004 | - |
dc.relation.journalcode | J00600 | - |
dc.identifier.eissn | 1600-0501 | - |
dc.identifier.pmid | 27726186 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1111/clr.12989 | - |
dc.subject.keyword | bone augmentation | - |
dc.subject.keyword | bone morphogenetic protein-2 | - |
dc.subject.keyword | dental implants | - |
dc.subject.keyword | deproteinized bovine bone mineral | - |
dc.subject.keyword | platelet-derived growth factor-BB | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Cha, Jae Kook | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Cha, Jae Kook | - |
dc.citation.volume | 28 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1134 | - |
dc.citation.endPage | 1341 | - |
dc.identifier.bibliographicCitation | CLINICAL ORAL IMPLANTS RESEARCH, Vol.28(11) : 1134-1341, 2017 | - |
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