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Localized bone regeneration around dental implants using recombinant bone morphogenetic protein-2 and platelet-derived growth factor-BB in the canine

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dc.contributor.author정의원-
dc.contributor.author차재국-
dc.date.accessioned2018-07-20T08:36:23Z-
dc.date.available2018-07-20T08:36:23Z-
dc.date.issued2017-
dc.identifier.issn0905-7161-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161318-
dc.description.abstractOBJECTIVES: To test whether or not one of two biological mediators (recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor (rhPDGF-BB)) is superior to the other and compared with control groups for bone regeneration around implants based on histomorphometrical outcome measures. MATERIALS AND METHODS: Box-type defects (10 × 5 × 5 mm) were prepared on the buccal sides of the left and right edentulous ridge in ten mongrel dogs. Implants were placed at each site, the defects either received (i) bovine-derived particulated bone mineral (DBBM) mixed with rhBMP-2 and a collagen membrane (CM) (DBBM/BMP-2), (ii) DBBM mixed with rhPDGF-BB and CM (DBBM/PDGF), (iii) DBBM and CM (DBBM) and (iv) empty control (control). Animals were euthanized post-surgery at 8 weeks and 16 weeks. Histomorphometrical analyses were performed. RESULTS: The mean percentages of regenerated area within total defect area amounted to 56.95% for DBBM/BMP-2, 48.86% for DBBM/PDFG, 33.44% for DBBM and 1.59% for control at 8 weeks, and 26.79% for DBBM/BMP-2, 23.78% for DBBM/PDFG, 30.21% for DBBM and 5.07% for control at 16 weeks with no statistically significant differences between the groups (P > 0.05). The mean amount of regenerated bone was 26.97% for DBBM/BMP-2, 22.02% for DBBM/PDFG, 5.03% for DBBM and 1.25% for control at 8 weeks, and at 16 weeks, these values were lower in the two groups with biological mediators (DBBM/BMP-2 = 13.35%; DBBM/PDGF = 6.96%) and only slightly increased in group DBBM (10.68%) and the control group (4.95%) compared with 8 weeks. The first bone-to-implant contact values on the buccal side were minimal for DBBM/BMP-2 (0.57 mm) and maximal for control (3.72 mm) at 8 weeks. CONCLUSIONS: The use of biological mediators (rhBMP-2 and rhPDGF-BB) can increase the amount of bone regeneration at dehiscence-type defects compared with controls at 8 weeks, but not at 16 weeks due to enhanced hard tissue remodeling processes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJohn Wiley and Sons, Inc.-
dc.relation.isPartOfCLINICAL ORAL IMPLANTS RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLocalized bone regeneration around dental implants using recombinant bone morphogenetic protein-2 and platelet-derived growth factor-BB in the canine-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Periodontology-
dc.contributor.googleauthorDaniel S. Thoma-
dc.contributor.googleauthorJae‐Kook Cha-
dc.contributor.googleauthorVitor M. Sapata-
dc.contributor.googleauthorRonald E. Jung-
dc.contributor.googleauthorJuerg Hüsler-
dc.contributor.googleauthorUi‐Won Jung-
dc.identifier.doi10.1111/clr.12989-
dc.contributor.localIdA03692-
dc.contributor.localIdA04004-
dc.relation.journalcodeJ00600-
dc.identifier.eissn1600-0501-
dc.identifier.pmid27726186-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/clr.12989-
dc.subject.keywordbone augmentation-
dc.subject.keywordbone morphogenetic protein-2-
dc.subject.keyworddental implants-
dc.subject.keyworddeproteinized bovine bone mineral-
dc.subject.keywordplatelet-derived growth factor-BB-
dc.contributor.alternativeNameJung, Ui Won-
dc.contributor.alternativeNameCha, Jae Kook-
dc.contributor.affiliatedAuthorJung, Ui Won-
dc.contributor.affiliatedAuthorCha, Jae Kook-
dc.citation.volume28-
dc.citation.number11-
dc.citation.startPage1134-
dc.citation.endPage1341-
dc.identifier.bibliographicCitationCLINICAL ORAL IMPLANTS RESEARCH, Vol.28(11) : 1134-1341, 2017-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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