Cited 6 times in
Inner nuclear layer cystoid spaces are a poor prognostic factor in typical age-related macular degeneration and polypoidal choroidal vasculopathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강의천 | - |
dc.contributor.author | 고형준 | - |
dc.contributor.author | 최서희 | - |
dc.date.accessioned | 2018-07-20T08:35:55Z | - |
dc.date.available | 2018-07-20T08:35:55Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0721-832X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161313 | - |
dc.description.abstract | PURPOSE: To investigate predictive factors for changes in best-corrected visual acuity (BCVA) at 24 months after intravitreal ranibizumab (IVR) for neovascular age-related macular degeneration (nAMD). METHODS: This retrospective study included 55 eyes of 55 consecutive patients (32 men and 23 women) with nAMD who received three consecutive monthly IVR injections and were re-treated as needed over a 24-month period. We used the mean changes in logarithm of the minimal angle of resolution (logMAR) BCVA at 24 months as the dependent variable in regression analysis. RESULTS: The presence of intraretinal cystoid spaces in the inner nuclear layer (INLc, P = 0.004) and baseline subfoveal choroidal thickness (SFCT, P = 0.013) predicted BCVA changes from baseline to 24 months. The presence of INLc and thinning of SFCT were associated with decreased BCVA at 24 months. Thirty-five eyes without INLc showed improved logMAR BCVA, from 0.550 ± 0.273 to 0.368 ± 0.274 (P = 0.045); however, 20 eyes with INLc showed decreased logMAR BCVA, from 0.708 ± 0.347 to 0.971 ± 0.523 (P < 0.001) through the 24-month follow-up. The mean number of IVR injections during the follow-up period was 8.74 ± 4.76 in eyes without INLc and 10.63 ± 4.72 in eyes with INLc, without a statistically significant difference (P = 0.144). CONCLUSION: Eyes with INLc or thinned SFCT showed worse visual outcomes compared with eyes without the INLc or with thick SFCT. Furthermore, eyes without INLc showed improved BCVA; however, eyes with INLc showed decreased BCVA with an as-needed regimen. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English, German | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angiogenesis Inhibitors/administration & dosage | - |
dc.subject.MESH | Cell Nucleus | - |
dc.subject.MESH | Choroid/blood supply* | - |
dc.subject.MESH | Choroid/diagnostic imaging | - |
dc.subject.MESH | Choroid Diseases/complications | - |
dc.subject.MESH | Choroid Diseases/diagnosis* | - |
dc.subject.MESH | Choroid Diseases/drug therapy | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorescein Angiography | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Fovea Centralis/diagnostic imaging* | - |
dc.subject.MESH | Fundus Oculi | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intravitreal Injections | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Polyps/complications | - |
dc.subject.MESH | Polyps/diagnosis* | - |
dc.subject.MESH | Polyps/drug therapy | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Ranibizumab/administration & dosage | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tomography, Optical Coherence | - |
dc.subject.MESH | Visual Acuity* | - |
dc.subject.MESH | Wet Macular Degeneration/complications | - |
dc.subject.MESH | Wet Macular Degeneration/diagnosis* | - |
dc.subject.MESH | Wet Macular Degeneration/drug therapy | - |
dc.title | Inner nuclear layer cystoid spaces are a poor prognostic factor in typical age-related macular degeneration and polypoidal choroidal vasculopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Ophthalmology | - |
dc.contributor.googleauthor | Eui Chun Kang | - |
dc.contributor.googleauthor | Seonghee Choi | - |
dc.contributor.googleauthor | Hyoung Jun Koh | - |
dc.identifier.doi | 10.1007/s00417-017-3776-9 | - |
dc.contributor.localId | A00073 | - |
dc.contributor.localId | A00152 | - |
dc.contributor.localId | A05052 | - |
dc.relation.journalcode | J00951 | - |
dc.identifier.eissn | 1435-702X | - |
dc.identifier.pmid | 28819823 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00417-017-3776-9 | - |
dc.subject.keyword | Age-related macular degeneration | - |
dc.subject.keyword | Choroidal thickness | - |
dc.subject.keyword | Inner nuclear layer cystoid spaces | - |
dc.subject.keyword | Spectral-domain optical coherence tomography | - |
dc.contributor.alternativeName | Kang, Eui Chun | - |
dc.contributor.alternativeName | Koh, Hyoung Jun | - |
dc.contributor.alternativeName | Choi, Seo Hee | - |
dc.contributor.affiliatedAuthor | Kang, Eui Chun | - |
dc.contributor.affiliatedAuthor | Koh, Hyoung Jun | - |
dc.contributor.affiliatedAuthor | Choi, Seo Hee | - |
dc.citation.volume | 255 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2157 | - |
dc.citation.endPage | 2163 | - |
dc.identifier.bibliographicCitation | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.255(11) : 2157-2163, 2017 | - |
dc.identifier.rimsid | 61235 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.