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Current status and future perspectives on treatment of liver metastasis in colorectal cancer (Review)

Authors
 Al Bandar  ;  Mahdi Hussain  ;  Kim Nam Kyu 
Citation
 ONCOLOGY REPORTS, Vol.37(5) : 2553-2564, 2017 
Journal Title
ONCOLOGY REPORTS
ISSN
 1021-335X 
Issue Date
2017
MeSH
Antineoplastic Agents/therapeutic use ; Colorectal Neoplasms/pathology ; Embolization, Therapeutic ; Hepatectomy/methods ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Molecular Targeted Therapy ; Neoadjuvant Therapy/methods ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/radiotherapy ; Portal Vein/surgery ; Quality of Life ; Radiotherapy/methods ; Rectal Neoplasms/pathology ; Rectal Neoplasms/radiotherapy
Abstract
Liver metastasis is the most common site of colorectal cancer (CRC) metastasis. Approximately half of all colorectal cancer patients will develop liver metastases. Although radical surgery is the standard treatment modality, only 10-20% of patients are deemed eligible for resection. Despite advances in survival with chemotherapy, surgical resection is still considered the only curative option for patients with liver metastases. Much effort has been expended to address patients with metastatic liver disease. The majority of evidence stated a significant survival benefit with surgical resection to reach an overall 5-year survival rate of 35-55% after hepatic resection. However, still majority of patients will experience disease recurrence even after a successful resection. In this review, we describe current status and controversies related to treatment options for CRC liver metastases and its potential for enhancing oncologic outcomes and improving quality of life.
Full Text
https://www.spandidos-publications.com/or/37/5/2553
DOI
10.3892/or.2017.5531
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161255
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