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Altered brain functional connectivity induced by physical exercise may improve neuropsychological functions in patients with benign epilepsy

Authors
 Gyan Raj Koirala  ;  Dongpyo Lee  ;  Soyong Eom  ;  Nam-Young Kim  ;  Heung Dong Kim 
Citation
 Epilepsy & Behavior, Vol.76 : 126-132, 2017 
Journal Title
 Epilepsy & Behavior 
ISSN
 1525-5050 
Issue Date
2017
MeSH
Adult ; Brain/physiopathology* ; Brain Mapping* ; Electroencephalography/methods* ; Epilepsy, Rolandic/diagnostic imaging* ; Epilepsy, Rolandic/physiopathology* ; Exercise/physiology* ; Exercise Therapy ; Female ; Humans ; Male ; Neuropsychological Tests
Keywords
Benign epilepsy ; Exercise ; Frequency bands ; Functional connectivity ; Neuropsychological functions ; Source localization
Abstract
OBJECTIVE: The objective of this study was to elucidate alteration in functional connectivity (FC) in patients with benign epilepsy with centrotemporal spikes (BECTS) as induced by physical exercise therapy and their correlation to the neuropsychological (NP) functions. METHODS: We analyzed 115 artifact- and spike-free 2-second epochs extracted from resting state EEG recordings before and after 5weeks of physical exercise in eight patients with BECTS. The exact Low Resolution Electromagnetic Tomography (eLORETA) was used for source reconstruction. We evaluated the cortical current source density (CSD) power across five different frequency bands (delta, theta, alpha, beta, and gamma). Altered FC between 34 regions of interests (ROIs) was then examined using lagged phase synchronization (LPS) method. We further investigated the correlation between the altered FC measures and the changes in NP test scores. RESULTS: We observed changes in CSD power following the exercise for all frequency bands and statistically significant increases in the right temporal region for the alpha band. There were a number of altered FC between the cortical ROIs in all frequency bands of interest. Furthermore, significant correlations were observed between FC measures and NP test scores at theta and alpha bands. CONCLUSION: The increased localization power at alpha band may be an indication of the positive impact of exercise in patients with BECTS. Frequency band-specific alterations in FC among cortical regions were associated with the modulation of cognitive and NP functions. The significant correlation between FC and NP tests suggests that physical exercise may mitigate the severity of BECTS, thereby enhancing NP function.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161252
DOI
10.1016/j.yebeh.2017.06.021
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김흥동(Kim, Heung Dong)
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Full Text
https://www.sciencedirect.com/science/article/pii/S1525505017302810
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