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4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes

Authors
 Chan Woo Kang  ;  Ye Eon Han  ;  Jean Kim  ;  Joo Heon Oh  ;  Yoon Hee Cho  ;  Eun Jig Lee 
Citation
 Scientific Reports, Vol.7(1) : 14192, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and re-epithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway. Therefore, 4-HBA could be a candidate therapeutic agent with the potential to promote acute wound healing.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161231
DOI
10.1038/s41598-017-14368-y
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute of Endocrinology (내분비연구소)
Yonsei Authors
이은직(Lee, Eun Jig) ; 조윤희(Cho, Yoon Hee)
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