Cited 5 times in
Somatic mutation driven codon transition bias in human cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강현덕 | - |
dc.contributor.author | 김상우 | - |
dc.contributor.author | 김현석 | - |
dc.date.accessioned | 2018-07-20T08:28:42Z | - |
dc.date.available | 2018-07-20T08:28:42Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161226 | - |
dc.description.abstract | Accumulation of DNA mutations alters amino acid sequence in the key domains of oncoproteins, leading to cellular malignant transformation. Due to redundancy of the genetic code, the same amino acid alteration can be achieved by multiple distinct genetic mutations, which are considered functionally identical and not actively distinguished in the current cancer genome research. For the first time, we analyzed the distribution of codon level transitions acquired by somatic mutations in human cancers. By analyzing the ~2.5 million nonsynonymous somatic single nucleotide variations (SNVs) found in the COSMIC database, we found 41 recurrent amino acid alterations whose DNA changes are significantly biased toward a specific codon transition. Additional analyses partially identified functional discrepancies between the favored and avoided codon transitions in terms of mutational process, codon usage, alternative splicing, and mRNA stability. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Somatic mutation driven codon transition bias in human cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Yonsei Biomedical Research Center | - |
dc.contributor.googleauthor | Hyeonju Son | - |
dc.contributor.googleauthor | Hyundeok Kang | - |
dc.contributor.googleauthor | Hyun Seok Kim | - |
dc.contributor.googleauthor | Sangwoo Kim | - |
dc.identifier.doi | 10.1038/s41598-017-14543-1 | - |
dc.contributor.localId | A05293 | - |
dc.contributor.localId | A00524 | - |
dc.contributor.localId | A01111 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 29079855 | - |
dc.contributor.alternativeName | Kang, Hyundeok | - |
dc.contributor.alternativeName | Kim, Sang Woo | - |
dc.contributor.alternativeName | Kim, Hyun Seok | - |
dc.contributor.affiliatedAuthor | Kang, Hyundeok | - |
dc.contributor.affiliatedAuthor | Kim, Sang Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Seok | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 14204 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.7(1) : 14204, 2017 | - |
dc.identifier.rimsid | 61149 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.