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소아 급성호흡곤란증후군에서 체외순환막장치 적용에 대한 RESP, PRESERVE, ECMOnet 점수 체계의 유용성

Other Titles
 Usefulness of the RESP, PRESERVE, and ECMOnet scores for extracorporeal membrane oxygenation in children with acute respiratory distress syndrome 
Authors
 안원기  ;  한정호  ;  김윤희  ;  설인숙  ;  윤서희  ;  김민정  ;  김경원  ;  손명현  ;  김규언 
Citation
 Allergy Asthma & Respiratory Disease, Vol.5(3) : 141-146, 2017 
Journal Title
 Allergy Asthma & Respiratory Disease 
ISSN
 2288-0402 
Issue Date
2017
Keywords
Extracorporeal membrane oxygenation ; Acute respiratory distress syndrome ; Survival ; Child
Abstract
Purpose: With increasing use of extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) in children, development of standardized strategies for survival prediction has become crucial; however, this has not been accomplished yet. We evaluated the adult scoring systems for survival prediction used for their applicability in pediatric ARDS and validated them. Methods: A total of 11 children with ARDS receiving ECMO from 2013 to 2014 were evaluated with adult scoring systems, including the Respiratory Extracorporeal-membrane-oxygenation Survival Prediction (RESP), the PRedicting dEath for SEvere ARDS on VVECMO (PRESERVE), and the ECMOnet scores. We compared the scores on these scales and the clinical characteristics between survivors and nonsurvivors. Results: Eight of the 11 children died (72.7%). The PRESERVE score (survivors vs. nonsurvivors: 2 vs. 5.25, P=0.048), and the ECMOnet score (4.1 vs. 5.63, P=0.048) were lower in survivors than in nonsurvivors. They correctly predicted mortality prediction. There was no significant difference in the RESP score between survivors and non-survivors (-4.33 vs. -2.62, P=0.63). The parameters that showed significant differences in this study were peak inspiratory pressure, platelet, and delta neutrophil index. All children who were under immunocompromised conditions, such as those with tumors, or underwent hematopoietic stem cell transplantation died. The immunocompromised status should be considered an important factor for survival prediction in children with ARDS. Conclusion: This is the first pilot study to apply the survival prediction scoring system to pediatric ARDS with ECMO. It is necessary to establish and modify the survival prediction score system for pediatric ARDS with ECMO.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161221
DOI
10.4168/aard.2017.5.3.141
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김경원(Kim, Kyung Won) ; 김규언(Kim, Kyu Earn) ; 김윤희(Kim, Yoon Hee) ; 설인숙(Sol, In Suk) ; 손명현(Sohn, Myung Hyun) ; 윤서희(Yoon, Seo Hee) ; 한정호(Han, Jung Ho)
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