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Cited 15 times in

Scar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model

DC FieldValueLanguage
dc.contributor.author김지희-
dc.contributor.author양채은-
dc.contributor.author이원재-
dc.contributor.author이주희-
dc.date.accessioned2018-07-20T08:20:05Z-
dc.date.available2018-07-20T08:20:05Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161100-
dc.description.abstractHigh-mobility group box protein-1 (HMGB-1) plays a central role in the inflammatory network, and uncontrolled chronic inflammation can lead to excessive scarring. The aim of this study was to evaluate the anti-inflammatory effects of polydeoxyribonucleotide (PDRN) on scar formation. Sprague-Dawley rats (n = 30) underwent dorsal excision of the skin, followed by skin repair. PDRN (8 mg/kg) was administered via intraperitoneal injection for three (PDRN-3 group, n = 8) or seven (PDRN-7 group, n = 8) days, and HMGB-1 was administered via intradermal injection in addition to PDRN treatment for three days (PDRN-3+HMGB-1 group; n = 6). The scar-reducing effects of PDRN were evaluated in the internal scar area and by inflammatory cell counts using histology and immunohistochemistry. Western blot, immunohistochemistry and immunofluorescence assays were performed to observe changes in type I and type III collagen and the expression of HMGB-1 and CD45. Treatment with PDRN significantly reduced the scar area, inflammatory cell infiltration and the number of CD45-positive cells. In addition, the increased expression of HMGB-1 observed in the sham group was significantly reduced after treatment with PDRN. Rats administered HMGB-1 in addition to PDRN exhibited scar areas with inflammatory cell infiltration similar to the sham group, and the collagen synthesis effects of PDRN were reversed. In summary, PDRN exerts anti-inflammatory and collagen synthesis effects via HMGB-1 suppression, preventing scar formation. Thus, we believe that the anti-inflammatory and collagen synthesis effects of PDRN resulted in faster wound healing and decreased scar formation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfInternational Journal of Molecular Sciences-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCicatrix/metabolism-
dc.subject.MESHCicatrix/pathology-
dc.subject.MESHCicatrix/prevention & control*-
dc.subject.MESHCollagen Type I/biosynthesis-
dc.subject.MESHCollagen Type III/biosynthesis-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHHMGB1 Protein/metabolism-
dc.subject.MESHMale-
dc.subject.MESHPolydeoxyribonucleotides/pharmacology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHWound Healing/drug effects*-
dc.subject.MESHWounds and Injuries/drug therapy*-
dc.subject.MESHWounds and Injuries/metabolism-
dc.subject.MESHWounds and Injuries/pathology-
dc.titleScar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Dermatology-
dc.contributor.googleauthorWoonhyeok Jeong-
dc.contributor.googleauthorChae Eun Yang-
dc.contributor.googleauthorTai Suk Roh-
dc.contributor.googleauthorJun Hyung Kim-
dc.contributor.googleauthorJu Hee Lee-
dc.contributor.googleauthorWon Jai Lee-
dc.identifier.doi10.3390/ijms18081698-
dc.contributor.localIdA04732-
dc.contributor.localIdA05360-
dc.contributor.localIdA03005-
dc.contributor.localIdA03171-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid28771195-
dc.subject.keywordcicatrix, inflammation-
dc.subject.keywordpolydeoxyribonucleotide-
dc.subject.keywordrats-
dc.subject.keywordwounds and injuries-
dc.contributor.alternativeNameKim, Jihee-
dc.contributor.alternativeNameYang, Chae Eun-
dc.contributor.alternativeNameLee, Won Jai-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.affiliatedAuthorKim, Jihee-
dc.contributor.affiliatedAuthorYang, Chae Eun-
dc.contributor.affiliatedAuthorLee, Won Jai-
dc.contributor.affiliatedAuthorLee, Ju Hee-
dc.citation.volume18-
dc.citation.number8-
dc.citation.startPageE1968-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, Vol.18(8) : E1968, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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