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Outcomes of Mycobacterium avium complex lung disease based on clinical phenotype

DC FieldValueLanguage
dc.contributor.author신성재-
dc.date.accessioned2018-07-20T08:19:07Z-
dc.date.available2018-07-20T08:19:07Z-
dc.date.issued2017-
dc.identifier.issn0903-1936-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161087-
dc.description.abstractThe effect of the clinical phenotype of Mycobacterium avium complex (MAC) lung disease on treatment outcome and redevelopment of nontuberculous mycobacterial (NTM) lung disease after treatment completion has not been studied systematically.We evaluated 481 treatment-naïve patients with MAC lung disease who underwent antibiotic treatment for ≥12 months between January 2002 and December 2013.Out of 481 patients, 278 (58%) had noncavitary nodular bronchiectatic (NB) disease, 80 (17%) had cavitary NB disease and 123 (25%) had fibrocavitary disease. Favourable outcome was higher in patients with noncavitary disease (88%) than in patients with cavitary disease (76% for fibrocavitary and 78% for cavitary NB disease; p<0.05). Cavitary disease was independently associated with unfavourable outcomes (p<0.05). Out of 402 patients with favourable outcomes, 118 (29%) experienced redevelopment of NTM lung disease, with the same MAC species recurring in 65 (55%) patients. The NB form was an independent risk factor for redevelopment of NTM lung disease (p<0.05). In patients with recurrent MAC lung disease due to the same species, bacterial genotyping revealed that 74% of cases were attributable to reinfection and 26% to relapse.Treatment outcomes and redevelopment of NTM lung disease after treatment completion differed by clinical phenotype of MAC lung disease.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherEuropean Respiratory Society-
dc.relation.isPartOfEuropean Respiratory Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleOutcomes of Mycobacterium avium complex lung disease based on clinical phenotype-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Microbiology-
dc.contributor.googleauthorWon-Jung Koh-
dc.contributor.googleauthorSeong Mi Moon-
dc.contributor.googleauthorSu-Young Kim-
dc.contributor.googleauthorMin-Ah Woo-
dc.contributor.googleauthorSeonwoo Kim-
dc.contributor.googleauthorByung Woo Jhun-
dc.contributor.googleauthorHye Yun Park-
dc.contributor.googleauthorKyeongman Jeon-
dc.contributor.googleauthorHee Jae Huh-
dc.contributor.googleauthorChang-Seok Ki-
dc.contributor.googleauthorNam Yong Lee-
dc.contributor.googleauthorMyung Jin Chung-
dc.contributor.googleauthorKyung Soo Lee-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorCharles L. Daley-
dc.contributor.googleauthorHojoong Kim-
dc.contributor.googleauthorO Jung Kwon-
dc.identifier.doi10.1183/13993003.02503-2016-
dc.contributor.localIdA02114-
dc.relation.journalcodeJ00852-
dc.identifier.eissn1399-3003-
dc.identifier.pmid28954780-
dc.identifier.urlhttp://erj.ersjournals.com/content/50/3/1602503.long-
dc.contributor.alternativeNameShin, Sung Jae-
dc.contributor.affiliatedAuthorShin, Sung Jae-
dc.citation.volume50-
dc.citation.number3-
dc.citation.startPage1602503-
dc.identifier.bibliographicCitationEuropean Respiratory Journal, Vol.50(3) : 1602503, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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