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Drug-induced Gingival Overgrowth Related to Sirolimus and Felodipine

Authors
 Youn-Jung Park  ;  Joo-Hee Lee  ;  Young-Gun Kim  ;  Jeong-Seung Kwon  ;  Hyung-Joon Ahn  ;  Jong-Hoon Choi 
Citation
 Journal of Oral Medicine and Pain, Vol.42(1) : 20-24, 2017 
Journal Title
 Journal of Oral Medicine and Pain 
ISSN
 2288-9272 
Issue Date
2017
Keywords
Calcium channel blockers ; Gingival overgrowth ; Immunosuppressive agents
Abstract
Drug-induced gingival overgrowth (DIGO) is an adverse drug reaction mainly described with three types of commonly prescribed drugs, namely, calcium channel blockers (CCBs) (nifedipine, diltiazem, and verapamil), anti-convulsants (phenytoin), and immunosuppressive agents (cyclosporine). Numerous reports have associated gingival overgrowth with the newer generation of immunosuppressive agents (tacrolimus, sirolimus, and everolimus), and CCBs (amlodipine, felodipine, nicardipine, and manidipine). Especially, patients concomitantly medicated with an immunosuppressive agent and CCB have a higher DIGO chance. Dentists need to be aware of drugs that induce gingival overgrowth, the possibility of DIGO, and risk factors, and also prevent the progression of DIGO by early detection of DIGO, consultation about the drug change, and the maintenance of strict dental hygiene regimes.
Files in This Item:
T201704027.pdf Download
DOI
10.14476/jomp.2017.42.1.20
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
권정승(Kwon, Jeong Seung) ORCID logo https://orcid.org/0000-0003-4584-7355
김영건(Kim, Young Gun)
박연정(Park, Youn-Jung) ORCID logo https://orcid.org/0000-0002-9152-7849
안형준(Ahn, Hyoung Joon)
최종훈(Choi, Jong Hoon) ORCID logo https://orcid.org/0000-0003-3211-3619
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161066
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