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Drug Resistance Patterns of Multidrug- and Extensively Drug-Resistant Tuberculosis in Korea: Amplification of Resistance to Oral Second-line Drugs

 Chang-Ki Kim  ;  So Youn Shin  ;  Hee Jin Kim  ;  Kyungwon Lee 
 Annals of Laboratory Medicine, Vol.37(4) : 323-326, 2017 
Journal Title
 Annals of Laboratory Medicine 
Issue Date
Administration, Oral ; Antitubercular Agents/pharmacology* ; Antitubercular Agents/therapeutic use ; Drug Resistance, Multiple, Bacterial/drug effects* ; Extensively Drug-Resistant Tuberculosis/diagnosis* ; Extensively Drug-Resistant Tuberculosis/microbiology ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Republic of Korea ; Tuberculosis, Multidrug-Resistant/diagnosis* ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology
Drug susceptibility testing ; Extensively drug-resistant tuberculosis ; Multidrug-resistant tuberculosis
We aimed to analyze the drug resistance patterns of multidrug-resistant and extensively drug-resistant tuberculosis (TB) and the difference of drug resistance among various settings for health care in Korea. The data of drug susceptibility testing in 2009 was analyzed in order to secure sufficient number of patients from various settings in Korea. Patients were categorized by types of institutions into four groups, which comprised new and previously treated patients from public health care centers (PHC), the private sector, and Double-barred Cross clinics (DBC). The resistance rates to first-line drugs were uniformly high in every group. While the resistance rates to second-line drugs were not as high as first-line drugs, there was a pattern that drug resistance rates were lowest for PHC and highest for DBC. The differences of the resistance rates were more prominent for oral second-line drugs. Our findings implied that drug resistance to oral second-line drugs was significantly amplified during multidrug-resistant-TB treatment in Korea. Therefore, an individualized approach is recommended for treating drug-resistant-TB based on susceptibility testing results to prevent acquisition or amplification of drug resistance.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
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