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Effect of shear-induced platelet activation on red blood cell aggregation

Authors
 Lee, Hoyoon  ;  Lee, Kisung  ;  Lee, Byoung-Kwon  ;  Priezzhev, Alexander V.  ;  Shin, Sehyun 
Citation
 Clinical Hemorheology and Microcirculation, Vol.66(2) : 97-104, 2017 
Journal Title
 Clinical Hemorheology and Microcirculation 
ISSN
 1386-0291 
Issue Date
2017
MeSH
Humans ; Male ; Platelet Activation/physiology* ; Platelet Aggregation/physiology* ; Stress, Mechanical
Keywords
CSS ; RBC ; aggregation ; platelet activation ; shear stress
Abstract
Mechanical shear stress is one of the important factors for platelet activation. Although shear stress has been frequently utilized in many applications of diagnostic bio-equipment, there has been little consideration as to whether shear stress induces platelet activation and consequently alters hemorheological characteristics. Therefore, we investigated the effect of shear-induced platelet activation on red blood cell (RBC) aggregation. The hypothesis of the present research is as follows: Platelets activated by high shear stress secrete substances, which can affect hemorheological characteristics to promote RBC aggregation. In our study, an increase in RBC aggregation indices (critical shear stress (CSS) and aggregation index (AI)) by shear-induced platelet activation was observed. Significantly, an increase of 19% in CSS was observed. However, deformability remained unchanged. These phenomena could be a result of the increased cellular adhesion force on RBC membranes due to secreted substances from activated platelets. Therefore, since high shear application results in the unexpected effect on RBC aggregation, conditions for shear application in diagnostic bio-equipment are to be carefully determined.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161063
DOI
10.3233/CH-16191
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
이병권(Lee, Byoung Kwon)
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https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch16191
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