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Comparing Outcomes Following Salvage Microsurgery in Vestibular Schwannoma Patients Failing Gamma-knife Radiosurgery or Microsurgery

Authors
 Lee, Hyun-Jin  ;  Kim, Mi Joo  ;  Koh, Seung Hyun  ;  Chang, Won Seok  ;  Moon, In Seok 
Citation
 OTOLOGY & NEUROTOLOGY, Vol.38(9) : 1339-1344, 2017 
Journal Title
OTOLOGY & NEUROTOLOGY
ISSN
 1531-7129 
Issue Date
2017
MeSH
Adult ; Facial Nerve/surgery ; Female ; Hearing Loss/pathology ; Hearing Loss/surgery* ; Humans ; Male ; Microsurgery* ; Middle Aged ; Neuroma, Acoustic/pathology ; Neuroma, Acoustic/surgery* ; Radiosurgery* ; Retrospective Studies ; Salvage Therapy ; Treatment Failure ; Treatment Outcome
Abstract
OBJECTIVE: The increasing use of primary gamma-knife radiosurgery (GKS) for the treatment of vestibular schwannoma (VS) has led to a concomitant increase in the number of patients requiring salvage surgery for GKS failure. When patients underwent GKS as the primary treatment, it is known that dissecting tumor from adjacent nerves during salvage surgery is more difficult. In this report, we share our clinical experience with such patients and analyze the clinical findings of patients with tumor regrowth/recurrence.

STUDY DESIGN: Retrospective chart review.

SETTING: Tertiary center.

PATIENTS: Nine patients who underwent salvage surgery for VS regrowth/recurrence after GKS or microsurgery were enrolled.

MAIN OUTCOME MEASURES: Symptom progression, radiological changes, intraoperative findings, and surgical outcomes were evaluated and compared.

RESULTS: Six patients with previous GKS and three with previous microsurgery underwent salvage microsurgery. The most obvious symptom of tumor regrowth was aggravation of hearing loss. Salvage surgery in all patients was limited to subtotal or near-total resection via a translabyrinthine/transotic approach. Severe adhesion, thickening, and fibrosis were more prominent findings in the GKS than in the previous microsurgery group. Dissection of the tumor from the facial nerve was more difficult in the GKS than in the microsurgery patients. Despite anatomical preservation of the facial nerve in all the six patients, three in the GKS group, but none in the revision microsurgery group, had worsening of facial nerve function.

CONCLUSION: Salvage microsurgery of VS after failed GKS is more difficult than revision microsurgery, and the facial nerve outcomes are relatively poor. Therefore, the primary method of VS treatment should be carefully chosen. Additional imaging studies are recommended in patients with a sudden change in hearing loss who underwent GKS.
Full Text
https://oce.ovid.com/article/00129492-201710000-00028/HTML
DOI
10.1097/MAO.0000000000001536
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Moon, In Seok(문인석) ORCID logo https://orcid.org/0000-0002-3951-5074
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161055
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