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Clinicopathological and prognostic significance of programmed death ligand-1 expression in breast cancer: a meta-analysis

DC Field Value Language
dc.contributor.author구자승-
dc.contributor.author김혜민-
dc.contributor.author이진애-
dc.date.accessioned2018-07-20T08:17:06Z-
dc.date.available2018-07-20T08:17:06Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161045-
dc.description.abstractBACKGROUND: Programmed cell death-ligand 1 (PD-L1) may be a useful molecule for targeted immunotherapy. Therefore, this meta-analysis aimed to investigate PD-L1 expression in breast cancer and its associations with clinicopathological factors and outcomes, which may help determine whether PD-L1 expression is a useful prognostic marker. METHODS: The Medline Ovid, Cochrane, PubMed, Google Scholar, and Web of Knowledge databases were searched for studies that evaluated the prognostic or clinicopathological significance of PD-L1 expression in patients with breast cancer, and reported at least one survival-related outcome. RESULTS: Six studies that included 7877 cases were selected for the analysis. Higher PD-L1 expression in all cells was related to higher histological grade and lymph node metastasis. Higher PD-L1 expression in tumor cell was related to larger tumor size, estrogen receptor negativity, progesterone receptor negativity, human epidermal growth factor type-2 positivity, and triple-negative breast cancer. PD-L1 positivity in all cells was associated with poorer disease-free survival, although it was not significantly associated with overall survival. CONCLUSION: The present meta-analysis revealed that cases of breast cancer with PD-L1 positivity in all cells exhibited higher histological grades, lymph node metastasis, and poorer disease-free survival. Therefore, positive expression of PD-L1 may be a useful prognostic marker in breast cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinicopathological and prognostic significance of programmed death ligand-1 expression in breast cancer: a meta-analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorHye Min Kim-
dc.contributor.googleauthorJinae Lee-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi10.1186/s12885-017-3670-1-
dc.contributor.localIdA00198-
dc.contributor.localIdA04553-
dc.contributor.localIdA04641-
dc.relation.journalcodeJ00351-
dc.identifier.eissn1471-2407-
dc.identifier.pmid29041905-
dc.subject.keywordBreast cancer-
dc.subject.keywordMeta-analysis-
dc.subject.keywordPD-L1-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Hye Min-
dc.contributor.alternativeNameLee, Jinae-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Hye Min-
dc.contributor.affiliatedAuthorLee, Jinae-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume17-
dc.citation.number1-
dc.citation.startPage690-
dc.identifier.bibliographicCitationBMC CANCER, Vol.17(1) : 690, 2017-
dc.identifier.rimsid60936-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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