15 18

Cited 0 times in

External validation of chemotherapy response score system for histopathological assessment of tumor regression after neoadjuvant chemotherapy in tubo-ovarian high-grade serous carcinoma

Authors
 Jung-Yun Lee  ;  Young Shin Chung  ;  Kiyong Na  ;  Hye Min Kim  ;  Cheol Keun Park  ;  Eun Ji Nam  ;  Sunghoon Kim  ;  Sang Wun Kim  ;  Young Tae Kim  ;  Hyun-Soo Kim 
Citation
 Journal of Gynecologic Oncology, Vol.28(6) : e73, 2017 
Journal Title
 Journal of Gynecologic Oncology 
ISSN
 2005-0380 
Issue Date
2017
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma/drug therapy* ; Carcinoma/pathology ; Cytoreduction Surgical Procedures ; Disease-Free Survival ; Fallopian Tube Neoplasms/drug therapy* ; Fallopian Tube Neoplasms/pathology ; Female ; Humans ; Middle Aged ; Neoadjuvant Therapy* ; Neoplasm Grading ; Neoplasm Staging ; Neoplasms, Cystic, Mucinous, and Serous/drug therapy* ; Neoplasms, Cystic, Mucinous, and Serous/pathology ; Omentum/surgery ; Ovarian Neoplasms/drug therapy* ; Ovarian Neoplasms/pathology ; Ovariectomy ; Proportional Hazards Models ; Reproducibility of Results ; Retrospective Studies ; Salpingectomy ; Treatment Outcome
Keywords
Chemotherapy Response Score ; Interval Debulking Surgery ; Neoadjuvant Chemotherapy ; Ovarian Neoplasms ; Progression-free Survival ; Tubo-ovarian High-grade Serous Carcinoma
Abstract
OBJECTIVE: The chemotherapy response score (CRS) system based on histopathological examination has been recently proposed for tubo-ovarian high-grade serous carcinoma (HGSC) to assess response to neoadjuvant chemotherapy (NAC). This study was aimed at validating the CRS system in an external cohort of tubo-ovarian HGSC patients. METHODS: This study included 110 tubo-ovarian HGSC patients who underwent NAC followed by interval debulking surgery. The 3-tiered CRS of the omental and adnexal tissue sections was determined by 3 independent pathologists. Differences in patient outcomes according to CRS were analyzed. RESULTS: The CRS system was highly reproducible among the 3 pathologists. Fleiss' kappa value and Kendall's coefficient of concordance for the omental CRS were 0.656 and 0.669, respectively. The omental CRS significantly predicted progression-free survival (PFS). The median PFS of patients whose tumors exhibited the omental CRS 1-2 (15 months) was significantly shorter than that of patients with an omental CRS of 3 (19 months; p=0.016). In addition, after adjusting for age, stage, and debulking status, the omental CRS was an independent prognostic factor for PFS of tubo-ovarian HGSC patients who were treated with NAC (adjusted hazard ratio [HR]=1.74; 95% confidence interval [CI]=1.05-2.87). CONCLUSION: The CRS system for assessing NAC response was a reproducible prognostic tool in our cohort. The application of the CRS system after NAC can improve survival estimation in HGSC patients.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161032
DOI
10.3802/jgo.2017.28.e73
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김상운(Kim, Sang Wun) ; 김성훈(Kim, Sung Hoon) ; 김영태(Kim, Young Tae) ; 김현수(Kim, Hyun-Soo) ; 김혜민(Kim, Hye Min) ; 남은지(Nam, Eun Ji) ; 이정윤(Lee, Jung-Yun) ; 정영신(Chung, Young Shin)
사서에게 알리기
  feedback
Files in This Item:
T201703927.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse